treatments equally effective across the biomarker signatures
By subgroup:
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| —+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +— | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +–+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
By signature:
| signature | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TP53- & AR- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| DRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
|
|
|
|
|
|
The overall error was 0.344.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.152 0.102 0.066 0.058
The overall power was .
The corresponding power separate for the different treatments were:
NULL
| signature | var | Carboplatin | Control | Hormone_therapies | Niraparib | Taxel_therapies |
|---|---|---|---|---|---|---|
| all | graduation | 1 | 0 | 11 | 1 | 4 |
| futility | 1 | 0 | 11 | 2 | 1 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 186 (130, 258) | 420 (386, 456) | 182 (119, 249) | 188 (132, 255) | 196 (133, 252) | |
| n_unique | 170 (117, 237) | 385 (354, 418) | 166 (108, 231) | 170 (118, 235) | 179 (120, 234) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | 6 (6, 7) | NA (NA, NA) | 4 (3, 6) | 7 (7, 15) | 5 (4, 10) | |
| post_p | 0.45 (0.1, 0.87) | NA (NA, NA) | 0.48 (0.08, 0.87) | 0.47 (0.08, 0.89) | 0.51 (0.09, 0.89) | |
| rate | 0.113 (0.102, 0.126) | 0.112 (0.104, 0.12) | 0.113 (0.101, 0.127) | 0.113 (0.102, 0.126) | 0.112 (0.101, 0.127) | |
| DRD+ | graduation | 2 | 0 | 3 | 2 | 1 |
| futility | 15 | 0 | 16 | 25 | 18 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 62 (43, 85) | 114 (98, 129) | 45 (25, 66) | 62 (42, 85) | 49 (30, 68) | |
| n_unique | 56 (38, 78) | 103 (89, 119) | 41 (23, 60) | 56 (36, 77) | 44 (27, 62) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | 24 (14, 32) | NA (NA, NA) | 30 (19, 34) | 22 (14, 35) | 28 (17, 32) | |
| post_p | 0.48 (0.1, 0.85) | NA (NA, NA) | 0.49 (0.11, 0.85) | 0.46 (0.11, 0.86) | 0.52 (0.13, 0.88) | |
| rate | 0.114 (0.098, 0.14) | 0.112 (0.098, 0.129) | 0.114 (0.091, 0.148) | 0.114 (0.096, 0.138) | 0.11 (0.092, 0.14) | |
| TEfus+ | graduation | 4 | 0 | 3 | 2 | 1 |
| futility | 17 | 0 | 29 | 26 | 24 | |
| max_n | 1 | 0 | 0 | 0 | 2 | |
| n | 71 (46, 100) | 152 (136, 173) | 66 (33, 96) | 71 (47, 98) | 79 (50, 104) | |
| n_unique | 65 (42, 92) | 139 (123, 159) | 60 (30, 86) | 64 (42, 89) | 72 (46, 96) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | 18 (11, 33) | NA (NA, NA) | 24 (15, 35) | 24 (14, 35) | 22 (10, 32) | |
| post_p | 0.47 (0.1, 0.87) | NA (NA, NA) | 0.49 (0.1, 0.86) | 0.47 (0.09, 0.88) | 0.52 (0.1, 0.88) | |
| rate | 0.114 (0.097, 0.139) | 0.112 (0.1, 0.125) | 0.114 (0.095, 0.142) | 0.113 (0.097, 0.139) | 0.112 (0.096, 0.134) | |
| TP53- & AR- | graduation | 24 | 0 | 50 | 22 | 44 |
| futility | 128 | 0 | 161 | 119 | 116 | |
| max_n | 12 | 0 | 17 | 18 | 13 | |
| n | 70 (29, 130) | 176 (152, 199) | 63 (26, 128) | 70 (29, 128) | 65 (27, 122) | |
| n_unique | 64 (26, 122) | 162 (138, 185) | 58 (25, 121) | 64 (27, 120) | 59 (24, 114) | |
| time_trial | 36 (18, 36) | 36 (36, 36) | 36 (9, 36) | 36 (19, 36) | 36 (17, 36) | |
| time_stop | 21 (12, 33) | NA (NA, NA) | 13 (7, 31) | 21 (13, 32) | 20 (11, 32) | |
| post_p | 0.45 (0.1, 0.88) | NA (NA, NA) | 0.45 (0.11, 0.86) | 0.45 (0.1, 0.88) | 0.47 (0.08, 0.91) | |
| rate | 0.115 (0.097, 0.143) | 0.112 (0.1, 0.124) | 0.115 (0.098, 0.141) | 0.114 (0.098, 0.141) | 0.114 (0.094, 0.144) | |
| TP53+ | graduation | 3 | 0 | 14 | 2 | 4 |
| futility | 32 | 0 | 38 | 31 | 33 | |
| max_n | 6 | 0 | 7 | 8 | 12 | |
| n | 86 (52, 123) | 186 (163, 207) | 86 (39, 123) | 84 (54, 122) | 91 (55, 131) | |
| n_unique | 78 (47, 113) | 169 (148, 188) | 79 (37, 113) | 76 (48, 110) | 82 (50, 120) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (30, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | 21 (12, 34) | NA (NA, NA) | 18 (8, 28) | 22 (12, 33) | 17 (10, 29) | |
| post_p | 0.48 (0.09, 0.87) | NA (NA, NA) | 0.47 (0.1, 0.9) | 0.48 (0.09, 0.89) | 0.5 (0.1, 0.89) | |
| rate | 0.113 (0.098, 0.137) | 0.111 (0.101, 0.126) | 0.113 (0.096, 0.133) | 0.114 (0.097, 0.134) | 0.113 (0.098, 0.133) |
| subtype | var | Carboplatin | Control | Hormone_therapies | Niraparib | Taxel_therapies |
|---|---|---|---|---|---|---|
| —- | graduation | 154 | 0 | 232 | 144 | 165 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 12 | 0 | 17 | 18 | 13 | |
| n | 37 (10, 89) | 111 (91, 132) | 35 (17, 93) | 33 (10, 91) | 32 (10, 87) | |
| n_unique | 34 (9, 84) | 103 (84, 124) | 33 (16, 91) | 31 (9, 86) | 30 (8, 84) | |
| post_p | 0.45 (0.11, 0.89) | NA (NA, NA) | 0.45 (0.11, 0.86) | 0.44 (0.1, 0.85) | 0.44 (0.08, 0.88) | |
| rate | 0.115 (0.093, 0.181) | 0.112 (0.099, 0.128) | 0.117 (0.096, 0.154) | 0.117 (0.095, 0.174) | 0.118 (0.093, 0.186) | |
| —+ | graduation | 169 | 0 | 239 | 154 | 180 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 13 | 0 | 17 | 18 | 15 | |
| n | 8 (2, 19) | 21 (14, 28) | 7 (2, 20) | 7 (2, 18) | 9 (3, 22) | |
| n_unique | 6 (1, 17) | 19 (13, 26) | 6 (2, 19) | 6 (2, 16) | 8 (2, 21) | |
| post_p | 0.44 (0.19, 0.82) | NA (NA, NA) | 0.48 (0.19, 0.84) | 0.42 (0.18, 0.83) | 0.47 (0.18, 0.85) | |
| rate | 0.128 (0.078, 0.338) | 0.113 (0.084, 0.159) | 0.12 (0.077, 0.276) | 0.131 (0.078, 0.333) | 0.125 (0.079, 0.235) | |
| –+- | graduation | 37 | 0 | 71 | 35 | 42 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 6 | 0 | 7 | 8 | 12 | |
| n | 23 (7, 54) | 63 (49, 77) | 26 (10, 58) | 23 (5, 54) | 23 (7, 53) | |
| n_unique | 21 (6, 51) | 57 (44, 72) | 25 (9, 54) | 21 (5, 50) | 21 (6, 49) | |
| post_p | 0.42 (0.11, 0.84) | NA (NA, NA) | 0.45 (0.12, 0.86) | 0.42 (0.11, 0.86) | 0.42 (0.12, 0.86) | |
| rate | 0.121 (0.09, 0.223) | 0.113 (0.094, 0.134) | 0.119 (0.091, 0.173) | 0.118 (0.089, 0.238) | 0.121 (0.091, 0.206) | |
| –++ | graduation | 55 | 0 | 92 | 60 | 60 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 7 | 0 | 7 | 8 | 14 | |
| n | 14 (4, 35) | 42 (32, 52) | 15 (4, 35) | 16 (4, 35) | 22 (7, 43) | |
| n_unique | 12 (3, 32) | 37 (29, 48) | 14 (4, 33) | 15 (4, 32) | 19 (7, 40) | |
| post_p | 0.43 (0.14, 0.83) | NA (NA, NA) | 0.44 (0.14, 0.83) | 0.45 (0.15, 0.85) | 0.46 (0.12, 0.88) | |
| rate | 0.124 (0.086, 0.26) | 0.111 (0.091, 0.142) | 0.121 (0.084, 0.228) | 0.12 (0.086, 0.242) | 0.117 (0.088, 0.191) | |
| -+– | graduation | 162 | 0 | 239 | 160 | 175 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 12 | 0 | 17 | 17 | 13 | |
| n | 10 (3, 21) | 21 (15, 28) | 5 (0, 17) | 10 (3, 21) | 7 (2, 18) | |
| n_unique | 8 (3, 20) | 19 (13, 26) | 4 (0, 16) | 9 (3, 20) | 6 (2, 16) | |
| post_p | 0.44 (0.18, 0.84) | NA (NA, NA) | 0.48 (0.2, 0.84) | 0.46 (0.17, 0.87) | 0.48 (0.18, 0.84) | |
| rate | 0.126 (0.084, 0.274) | 0.113 (0.085, 0.157) | 0.123 (0.074, 0.332) | 0.12 (0.08, 0.302) | 0.121 (0.074, 0.335) | |
| -+-+ | graduation | 177 | 0 | 246 | 169 | 188 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 13 | 0 | 17 | 17 | 15 | |
| n | 9 (3, 22) | 21 (15, 28) | 5 (0, 18) | 10 (3, 22) | 7 (2, 18) | |
| n_unique | 8 (3, 20) | 19 (14, 26) | 4 (0, 16) | 9 (3, 20) | 6 (1, 16) | |
| post_p | 0.43 (0.16, 0.84) | NA (NA, NA) | 0.45 (0.18, 0.83) | 0.47 (0.17, 0.86) | 0.48 (0.18, 0.84) | |
| rate | 0.128 (0.084, 0.289) | 0.113 (0.083, 0.155) | 0.13 (0.075, 0.408) | 0.122 (0.08, 0.31) | 0.123 (0.073, 0.344) | |
| -++- | graduation | 50 | 0 | 87 | 58 | 59 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 6 | 0 | 7 | 8 | 12 | |
| n | 6 (2, 13) | 12 (7, 16) | 4 (1, 11) | 6 (2, 13) | 5 (1, 10) | |
| n_unique | 5 (2, 12) | 10 (6, 15) | 4 (1, 9) | 5 (2, 12) | 4 (1, 10) | |
| post_p | 0.47 (0.21, 0.83) | NA (NA, NA) | 0.43 (0.23, 0.8) | 0.44 (0.2, 0.84) | 0.47 (0.23, 0.81) | |
| rate | 0.124 (0.072, 0.33) | 0.115 (0.073, 0.181) | 0.134 (0.07, 0.43) | 0.133 (0.073, 0.375) | 0.128 (0.064, 0.48) | |
| -+++ | graduation | 68 | 0 | 107 | 79 | 74 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 7 | 0 | 7 | 8 | 14 | |
| n | 6 (2, 13) | 12 (7, 17) | 4 (1, 11) | 6 (2, 13) | 4 (1, 11) | |
| n_unique | 5 (2, 12) | 10 (7, 16) | 4 (1, 10) | 5 (2, 12) | 4 (1, 10) | |
| post_p | 0.46 (0.2, 0.82) | NA (NA, NA) | 0.47 (0.21, 0.84) | 0.44 (0.2, 0.84) | 0.45 (0.19, 0.81) | |
| rate | 0.123 (0.07, 0.328) | 0.111 (0.074, 0.182) | 0.126 (0.065, 0.379) | 0.128 (0.071, 0.411) | 0.132 (0.067, 0.415) | |
| +— | graduation | 2 | 0 | 22 | 3 | 5 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 8 (2, 17) | 21 (14, 27) | 9 (3, 19) | 8 (3, 17) | 10 (4, 22) | |
| n_unique | 7 (2, 16) | 19 (12, 25) | 8 (2, 18) | 7 (2, 16) | 10 (3, 20) | |
| post_p | 0.43 (0.18, 0.8) | NA (NA, NA) | 0.49 (0.19, 0.82) | 0.45 (0.19, 0.84) | 0.48 (0.17, 0.86) | |
| rate | 0.132 (0.076, 0.335) | 0.115 (0.084, 0.161) | 0.125 (0.078, 0.322) | 0.125 (0.078, 0.301) | 0.121 (0.082, 0.272) | |
| +–+ | graduation | 23 | 0 | 53 | 31 | 30 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 1 | 0 | 0 | 0 | 2 | |
| n | 6 (2, 15) | 16 (11, 22) | 7 (2, 15) | 6 (2, 14) | 9 (3, 18) | |
| n_unique | 5 (2, 13) | 15 (10, 20) | 6 (2, 14) | 5 (2, 13) | 8 (3, 16) | |
| post_p | 0.46 (0.2, 0.82) | NA (NA, NA) | 0.46 (0.2, 0.85) | 0.45 (0.22, 0.82) | 0.46 (0.2, 0.84) | |
| rate | 0.13 (0.075, 0.388) | 0.116 (0.086, 0.168) | 0.132 (0.08, 0.354) | 0.131 (0.074, 0.426) | 0.127 (0.079, 0.252) | |
| +-+- | graduation | 37 | 0 | 71 | 35 | 42 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 6 | 0 | 7 | 8 | 12 | |
| n | 6 (2, 14) | 16 (11, 22) | 6 (2, 15) | 6 (2, 14) | 8 (3, 17) | |
| n_unique | 6 (2, 13) | 15 (10, 20) | 6 (1, 14) | 6 (2, 13) | 8 (2, 16) | |
| post_p | 0.45 (0.2, 0.8) | NA (NA, NA) | 0.45 (0.21, 0.83) | 0.45 (0.21, 0.81) | 0.48 (0.18, 0.85) | |
| rate | 0.131 (0.075, 0.334) | 0.113 (0.076, 0.17) | 0.123 (0.072, 0.415) | 0.129 (0.071, 0.349) | 0.123 (0.077, 0.289) | |
| +-++ | graduation | 55 | 0 | 92 | 60 | 60 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 7 | 0 | 7 | 8 | 14 | |
| n | 7 (2, 15) | 16 (11, 23) | 5 (2, 15) | 6 (2, 14) | 9 (3, 17) | |
| n_unique | 6 (2, 14) | 15 (10, 21) | 5 (1, 14) | 5 (2, 13) | 8 (3, 16) | |
| post_p | 0.45 (0.2, 0.82) | NA (NA, NA) | 0.44 (0.19, 0.82) | 0.44 (0.18, 0.82) | 0.46 (0.18, 0.87) | |
| rate | 0.128 (0.075, 0.335) | 0.113 (0.079, 0.164) | 0.133 (0.078, 0.364) | 0.128 (0.074, 0.38) | 0.123 (0.077, 0.262) | |
| ++– | graduation | 19 | 0 | 40 | 29 | 24 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 6 (2, 13) | 12 (7, 17) | 4 (1, 10) | 6 (2, 14) | 4 (1, 11) | |
| n_unique | 6 (2, 12) | 10 (6, 16) | 4 (1, 9) | 6 (2, 13) | 4 (1, 10) | |
| post_p | 0.47 (0.2, 0.83) | NA (NA, NA) | 0.44 (0.2, 0.8) | 0.44 (0.22, 0.82) | 0.46 (0.22, 0.81) | |
| rate | 0.121 (0.067, 0.331) | 0.113 (0.072, 0.165) | 0.137 (0.062, 0.448) | 0.128 (0.075, 0.372) | 0.127 (0.063, 0.468) | |
| ++-+ | graduation | 39 | 0 | 69 | 53 | 46 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 1 | 0 | 0 | 0 | 2 | |
| n | 6 (2, 12) | 12 (7, 17) | 4 (1, 10) | 6 (2, 13) | 5 (1, 11) | |
| n_unique | 5 (2, 11) | 11 (7, 16) | 4 (1, 9) | 5 (2, 12) | 4 (1, 10) | |
| post_p | 0.44 (0.19, 0.8) | NA (NA, NA) | 0.44 (0.2, 0.79) | 0.45 (0.2, 0.83) | 0.44 (0.21, 0.78) | |
| rate | 0.131 (0.073, 0.347) | 0.112 (0.075, 0.17) | 0.133 (0.068, 0.388) | 0.129 (0.074, 0.357) | 0.134 (0.065, 0.458) | |
| +++- | graduation | 50 | 0 | 87 | 58 | 59 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 6 | 0 | 7 | 8 | 12 | |
| n | 6 (2, 13) | 12 (7, 17) | 4 (1, 10) | 6 (2, 13) | 5 (1, 11) | |
| n_unique | 5 (2, 12) | 11 (6, 16) | 4 (1, 9) | 5 (2, 11) | 4 (1, 10) | |
| post_p | 0.47 (0.2, 0.81) | NA (NA, NA) | 0.47 (0.22, 0.77) | 0.44 (0.19, 0.8) | 0.47 (0.21, 0.82) | |
| rate | 0.125 (0.074, 0.316) | 0.115 (0.072, 0.182) | 0.129 (0.067, 0.39) | 0.129 (0.076, 0.386) | 0.127 (0.064, 0.412) | |
| ++++ | graduation | 68 | 0 | 107 | 79 | 74 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 7 | 0 | 7 | 8 | 14 | |
| n | 6 (2, 13) | 12 (7, 17) | 4 (1, 11) | 5 (2, 13) | 4 (1, 11) | |
| n_unique | 6 (2, 12) | 10 (6, 16) | 4 (1, 10) | 5 (2, 11) | 4 (1, 9) | |
| post_p | 0.48 (0.2, 0.81) | NA (NA, NA) | 0.45 (0.24, 0.83) | 0.43 (0.19, 0.83) | 0.45 (0.21, 0.82) | |
| rate | 0.125 (0.074, 0.334) | 0.115 (0.077, 0.174) | 0.132 (0.064, 0.411) | 0.139 (0.075, 0.386) | 0.131 (0.065, 0.469) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 11 | 4 | 1 | 1 |
| time_stop | 4 (4, 6) | 4 (4, 11) | 6 (6, 6) | 7 (7, 7) | |
| n_trt | 34 (25, 50) | 30 (26, 50) | 25 (25, 25) | 27 (27, 27) | |
| n_control | 52 (37, 61) | 54 (50, 108) | 51 (51, 51) | 80 (80, 80) | |
| post_p | 0.87 (0.85, 0.96) | 0.93 (0.92, 0.98) | 0.98 (0.98, 0.98) | 0.97 (0.97, 0.97) | |
| order | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | |
| TP53- & AR- | count | 50 | 44 | 24 | 22 |
| time_stop | 10 (6, 21) | 14 (9, 27) | 15 (10, 27) | 14 (9, 21) | |
| n_trt | 31 (26, 66) | 36 (26, 69) | 33 (25, 68) | 30 (26, 50) | |
| n_control | 43 (27, 100) | 60 (40, 116) | 62 (37, 125) | 61 (41, 87) | |
| post_p | 0.9 (0.87, 0.95) | 0.94 (0.86, 0.99) | 0.94 (0.86, 0.99) | 0.95 (0.9, 0.98) | |
| order | 1 (1, 1) | 1 (1, 2) | 1 (1, 1.7) | 1 (1, 1) | |
| TP53+ | count | 14 | 4 | 3 | 2 |
| time_stop | 10 (7, 14) | 10 (8, 13) | 12 (10, 13) | 11 (10, 12) | |
| n_trt | 28 (25, 39) | 33 (31, 42) | 33 (27, 35) | 39 (30, 48) | |
| n_control | 42 (32, 62) | 41 (32, 59) | 49 (35, 60) | 42 (33, 50) | |
| post_p | 0.94 (0.86, 0.97) | 0.96 (0.94, 0.98) | 0.94 (0.94, 0.95) | 0.92 (0.87, 0.96) | |
| order | 1 (1, 2) | 1 (1, 1.7) | 1 (1, 1) | 1 (1, 1) | |
| DRD+ | count | 3 | 1 | 2 | 2 |
| time_stop | 21 (15, 22) | 17 (17, 17) | 16 (14, 18) | 10 (10, 10) | |
| n_trt | 25 (25, 34) | 26 (26, 26) | 27 (25, 29) | 28 (26, 30) | |
| n_control | 53 (31, 64) | 47 (47, 47) | 35 (33, 37) | 30 (26, 33) | |
| post_p | 0.98 (0.88, 0.98) | 0.92 (0.92, 0.92) | 0.88 (0.86, 0.9) | 0.94 (0.91, 0.98) | |
| order | 1 (1, 1.8) | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | |
| TEfus+ | count | 3 | 1 | 4 | 2 |
| time_stop | 13 (11, 15) | 11 (11, 11) | 11 (10, 14) | 15 (13, 17) | |
| n_trt | 26 (25, 32) | 31 (31, 31) | 28 (26, 29) | 41 (39, 43) | |
| n_control | 44 (40, 52) | 36 (36, 36) | 42 (40, 50) | 50 (40, 60) | |
| post_p | 0.9 (0.87, 0.94) | 0.95 (0.95, 0.95) | 0.93 (0.87, 0.99) | 1 (1, 1) | |
| order | 1 (1, 1.8) | 1 (1, 1) | 1 (1, 1.7) | 1 (1, 1) |
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 11 | 1 | 1 | 2 |
| time_stop | 5 (3, 5) | 6 (6, 6) | 7 (7, 7) | 12 (8, 16) | |
| n_trt | 31 (25, 39) | 28 (28, 28) | 38 (38, 38) | 41 (32, 50) | |
| n_control | 43 (33, 66) | 75 (75, 75) | 64 (64, 64) | 140 (92, 187) | |
| post_p | 0.04 (0.03, 0.28) | 0.14 (0.14, 0.14) | 0.01 (0.01, 0.01) | 0.06 (0.01, 0.11) | |
| order | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | 1.5 (1.1, 1.9) | |
| TP53- & AR- | count | 161 | 116 | 128 | 119 |
| time_stop | 15 (8, 32) | 22 (15, 33) | 22 (14, 34) | 22 (14, 33) | |
| n_trt | 36 (25, 75) | 36 (25, 72) | 34 (25, 80) | 39 (26, 84) | |
| n_control | 65 (30, 147) | 101 (66, 158) | 102 (59, 167) | 101 (59, 159) | |
| post_p | 0.17 (0.06, 0.28) | 0.12 (0.03, 0.27) | 0.16 (0.04, 0.26) | 0.16 (0.06, 0.28) | |
| order | 1 (1, 2) | 2 (1, 3) | 1 (1, 3) | 2 (1, 3) | |
| TP53+ | count | 38 | 33 | 32 | 31 |
| time_stop | 20 (10, 28) | 18 (10, 29) | 22 (14, 34) | 22 (13, 33) | |
| n_trt | 42 (26, 69) | 41 (28, 69) | 44 (26, 75) | 45 (27, 74) | |
| n_control | 94 (38, 139) | 85 (42, 159) | 100 (66, 182) | 107 (59, 171) | |
| post_p | 0.06 (0.01, 0.22) | 0.07 (0.03, 0.21) | 0.05 (0.01, 0.15) | 0.05 (0, 0.13) | |
| order | 1 (1, 3) | 2 (1, 3) | 1 (1, 3) | 2 (1, 4) | |
| DRD+ | count | 16 | 18 | 15 | 25 |
| time_stop | 31 (22, 35) | 28 (22, 33) | 24 (16, 33) | 23 (16, 36) | |
| n_trt | 32 (26, 49) | 31 (25, 49) | 37 (25, 51) | 34 (28, 54) | |
| n_control | 98 (64, 120) | 84 (55, 99) | 68 (45, 90) | 69 (40, 114) | |
| post_p | 0.05 (0.02, 0.15) | 0.04 (0.01, 0.19) | 0.08 (0.02, 0.18) | 0.04 (0.02, 0.17) | |
| order | 2 (1.5, 4) | 2.5 (1.7, 4) | 3 (1.4, 4) | 2 (1, 3) | |
| TEfus+ | count | 29 | 24 | 17 | 26 |
| time_stop | 25 (18, 35) | 22 (11, 32) | 20 (13, 33) | 24 (14, 36) | |
| n_trt | 34 (26, 49) | 40 (28, 62) | 33 (26, 49) | 44 (26, 70) | |
| n_control | 105 (65, 140) | 90 (36, 126) | 88 (49, 137) | 93 (46, 150) | |
| post_p | 0.05 (0.02, 0.13) | 0.05 (0.01, 0.13) | 0.05 (0.02, 0.11) | 0.04 (0.01, 0.16) | |
| order | 2 (1, 4) | 1.5 (1, 3) | 2 (1, 3.4) | 2 (1, 3.5) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Carboplatin | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| time | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | ||
| n | 6 (6, 6) | 0 (0, 0) | 4 (4, 4) | 0 (0, 0) | 2 (2, 2) | 4 (4, 4) | 0 (0, 0) | 2 (2, 2) | 1 (1, 1) | 0 (0, 0) | 2 (2, 2) | 0 (0, 0) | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | ||
| post_p | 0.56 (0.56, 0.56) | NA (NA, NA) | 0.56 (0.56, 0.56) | NA (NA, NA) | 0.67 (0.67, 0.67) | 0.73 (0.73, 0.73) | NA (NA, NA) | 0.58 (0.58, 0.58) | 0.62 (0.62, 0.62) | NA (NA, NA) | 0.59 (0.59, 0.59) | NA (NA, NA) | 0.63 (0.63, 0.63) | 0.51 (0.51, 0.51) | 0.54 (0.54, 0.54) | 0.52 (0.52, 0.52) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.091 (0.091, 0.091) | NA (NA, NA) | 0.087 (0.087, 0.087) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| Hormone_therapies | count | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | |
| time | 4 (4, 6) | 4 (4, 6) | 4 (4, 6) | 4 (4, 6) | 4 (4, 6) | 4 (4, 6) | 4 (4, 6) | 4 (4, 6) | 4 (4, 6) | 4 (4, 6) | 4 (4, 6) | 4 (4, 6) | 4 (4, 6) | 4 (4, 6) | 4 (4, 6) | 4 (4, 6) | ||
| n | 14 (11, 19) | 1 (1, 3) | 9 (8, 18) | 2 (0, 5) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 3) | 1 (1, 3) | 1 (1, 3) | 1 (0, 1) | 0 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | ||
| post_p | 0.64 (0.55, 0.88) | 0.58 (0.54, 0.65) | 0.73 (0.62, 0.83) | 0.59 (0.53, 0.71) | NA (NA, NA) | 0.54 (0.54, 0.63) | NA (NA, NA) | 0.6 (0.52, 0.77) | 0.55 (0.51, 0.69) | 0.59 (0.51, 0.7) | 0.62 (0.54, 0.64) | 0.6 (0.54, 0.6) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.61 (0.56, 0.65) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.078 (0.047, 0.113) | 0 (0, 0.007) | 0.057 (0, 0.092) | 0 (0, 0.305) | NA (NA, NA) | 0 (0, 0.112) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0.077) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.088) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | ||
| Niraparib | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| time | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | ||
| n | 2 (2, 2) | 0 (0, 0) | 4 (4, 4) | 2 (2, 2) | 6 (6, 6) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 1 (1, 1) | 2 (2, 2) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 4 (4, 4) | 2 (2, 2) | 2 (2, 2) | ||
| post_p | 0.54 (0.54, 0.54) | NA (NA, NA) | 0.7 (0.7, 0.7) | 0.61 (0.61, 0.61) | 0.62 (0.62, 0.62) | NA (NA, NA) | NA (NA, NA) | 0.58 (0.58, 0.58) | 0.51 (0.51, 0.51) | 0.51 (0.51, 0.51) | NA (NA, NA) | 0.54 (0.54, 0.54) | NA (NA, NA) | 0.73 (0.73, 0.73) | 0.64 (0.64, 0.64) | 0.82 (0.82, 0.82) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0.044 (0.044, 0.044) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0.068 (0.068, 0.068) | 0 (0, 0) | 0 (0, 0) | ||
| Taxel_therapies | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |
| time | 4 (4, 11) | 4 (4, 11) | 4 (4, 11) | 4 (4, 11) | 4 (4, 11) | 4 (4, 11) | 4 (4, 11) | 4 (4, 11) | 4 (4, 11) | 4 (4, 11) | 4 (4, 11) | 4 (4, 11) | 4 (4, 11) | 4 (4, 11) | 4 (4, 11) | 4 (4, 11) | ||
| n | 6 (4, 8) | 2 (1, 5) | 7 (2, 8) | 6 (4, 8) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 4) | 4 (2, 6) | 4 (2, 4) | 4 (1, 6) | 0 (0, 2) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | ||
| post_p | 0.71 (0.61, 0.83) | 0.58 (0.54, 0.69) | 0.64 (0.63, 0.75) | 0.72 (0.65, 0.8) | 0.59 (0.59, 0.59) | 0.61 (0.61, 0.61) | 0.55 (0.53, 0.58) | 0.52 (0.52, 0.52) | 0.64 (0.63, 0.64) | 0.6 (0.51, 0.83) | 0.61 (0.53, 0.72) | 0.58 (0.53, 0.83) | 0.51 (0.51, 0.51) | NA (NA, NA) | 0.57 (0.57, 0.57) | NA (NA, NA) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.038 (0, 0.099) | 0 (0, 0.121) | 0.068 (0.014, 0.096) | 0 (0, 0.049) | 0.119 (0.119, 0.119) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.163 (0.091, 0.235) | 0 (0, 0) | 0.033 (0, 0.187) | 0.114 (0.023, 0.252) | 0 (0, 0) | NA (NA, NA) | 0.073 (0.073, 0.073) | NA (NA, NA) | ||
| DRD+ | Carboplatin | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||
| time | 16 (14, 18) | 16 (14, 18) | 16 (14, 18) | 16 (14, 18) | 16 (14, 18) | 16 (14, 18) | 16 (14, 18) | 16 (14, 18) | ||||||||||
| n | 6 (4, 8) | 4 (2, 5) | 4 (4, 4) | 2 (0, 3) | 2 (0, 4) | 2 (2, 3) | 2 (1, 4) | 4 (2, 7) | ||||||||||
| post_p | 0.66 (0.59, 0.73) | 0.56 (0.55, 0.57) | 0.62 (0.6, 0.64) | 0.56 (0.56, 0.56) | 0.77 (0.77, 0.77) | 0.65 (0.61, 0.68) | 0.57 (0.54, 0.6) | 0.71 (0.55, 0.87) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.069 (0.033, 0.105) | 0.127 (0.124, 0.13) | 0.061 (0.052, 0.069) | 0.201 (0.201, 0.201) | 0.057 (0.057, 0.057) | 0.064 (0.013, 0.116) | 0.03 (0.006, 0.054) | 0.054 (0.011, 0.098) | ||||||||||
| Hormone_therapies | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||||||
| time | 21 (15, 22) | 21 (15, 22) | 21 (15, 22) | 21 (15, 22) | 21 (15, 22) | 21 (15, 22) | 21 (15, 22) | 21 (15, 22) | ||||||||||
| n | 5 (1, 5) | 9 (3, 11) | 3 (1, 8) | 4 (1, 4) | 1 (1, 3) | 5 (2, 6) | 4 (2, 5) | 3 (1, 3) | ||||||||||
| post_p | 0.6 (0.57, 0.62) | 0.78 (0.68, 0.89) | 0.68 (0.54, 0.83) | 0.59 (0.56, 0.62) | 0.65 (0.63, 0.69) | 0.68 (0.62, 0.76) | 0.56 (0.53, 0.59) | 0.68 (0.58, 0.82) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.098 (0.092, 0.103) | 0.084 (0.046, 0.09) | 0.102 (0.05, 0.154) | 0.084 (0.068, 0.099) | 0 (0, 0) | 0.087 (0.065, 0.124) | 0.08 (0.016, 0.174) | 0 (0, 0.045) | ||||||||||
| Niraparib | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |||||||||
| time | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | ||||||||||
| n | 3 (3, 3) | 6 (5, 7) | 2 (2, 3) | 2 (2, 3) | 3 (2, 4) | 4 (4, 5) | 3 (3, 3) | 4 (2, 6) | ||||||||||
| post_p | 0.64 (0.59, 0.68) | 0.74 (0.7, 0.79) | 0.83 (0.81, 0.84) | 0.72 (0.62, 0.82) | 0.61 (0.6, 0.62) | 0.75 (0.64, 0.86) | 0.55 (0.55, 0.56) | 0.67 (0.54, 0.8) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.036 (0.007, 0.064) | 0.101 (0.068, 0.133) | 0 (0, 0) | 0.107 (0.021, 0.193) | 0.029 (0.006, 0.052) | 0.035 (0.034, 0.036) | 0.117 (0.114, 0.12) | 0.039 (0.008, 0.07) | ||||||||||
| Taxel_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 17 (17, 17) | 17 (17, 17) | 17 (17, 17) | 17 (17, 17) | 17 (17, 17) | 17 (17, 17) | 17 (17, 17) | 17 (17, 17) | ||||||||||
| n | 3 (3, 3) | 5 (5, 5) | 2 (2, 2) | 1 (1, 1) | 1 (1, 1) | 3 (3, 3) | 9 (9, 9) | 2 (2, 2) | ||||||||||
| post_p | 0.6 (0.6, 0.6) | 0.57 (0.57, 0.57) | 0.85 (0.85, 0.85) | 0.68 (0.68, 0.68) | 0.74 (0.74, 0.74) | 0.61 (0.61, 0.61) | 0.81 (0.81, 0.81) | 0.54 (0.54, 0.54) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.051 (0.051, 0.051) | 0.094 (0.094, 0.094) | 0.064 (0.064, 0.064) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.077 (0.077, 0.077) | 0 (0, 0) | ||||||||||
| TEfus+ | Carboplatin | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | ||||||||
| time | 11 (10, 14) | 11 (10, 14) | 11 (10, 14) | 11 (10, 14) | 11 (10, 14) | 11 (10, 14) | 11 (10, 14) | 11 (10, 14) | ||||||||||
| n | 4 (2, 7) | 4 (2, 8) | 6 (3, 7) | 4 (3, 5) | 4 (2, 5) | 0 (0, 2) | 2 (0, 4) | 4 (2, 4) | ||||||||||
| post_p | 0.74 (0.6, 0.86) | 0.62 (0.57, 0.85) | 0.64 (0.51, 0.85) | 0.61 (0.54, 0.85) | 0.57 (0.52, 0.73) | 0.54 (0.54, 0.55) | 0.71 (0.61, 0.8) | 0.58 (0.56, 0.65) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.027 (0, 0.083) | 0 (0, 0.079) | 0.061 (0.053, 0.09) | 0.073 (0.059, 0.1) | 0.042 (0, 0.135) | 0 (0, 0) | 0.094 (0.082, 0.106) | 0.09 (0.073, 0.097) | ||||||||||
| Hormone_therapies | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||||||
| time | 13 (11, 15) | 13 (11, 15) | 13 (11, 15) | 13 (11, 15) | 13 (11, 15) | 13 (11, 15) | 13 (11, 15) | 13 (11, 15) | ||||||||||
| n | 4 (2, 5) | 13 (12, 17) | 2 (1, 6) | 0 (0, 2) | 3 (1, 4) | 3 (1, 4) | 0 (0, 1) | 0 (0, 1) | ||||||||||
| post_p | 0.66 (0.6, 0.71) | 0.73 (0.71, 0.75) | 0.56 (0.55, 0.88) | 0.62 (0.62, 0.62) | 0.77 (0.65, 0.78) | 0.58 (0.54, 0.63) | 0.56 (0.56, 0.56) | NA (NA, NA) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.098 (0.02, 0.099) | 0.091 (0.076, 0.104) | 0.032 (0.006, 0.085) | 0 (0, 0) | 0.079 (0.016, 0.1) | 0.066 (0.059, 0.074) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| Niraparib | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |||||||||
| time | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | ||||||||||
| n | 4 (3, 4) | 12 (11, 14) | 6 (5, 8) | 6 (4, 8) | 4 (2, 6) | 1 (1, 1) | 4 (3, 5) | 4 (3, 4) | ||||||||||
| post_p | 0.56 (0.53, 0.58) | 0.83 (0.81, 0.86) | 0.75 (0.72, 0.78) | 0.77 (0.76, 0.79) | 0.75 (0.7, 0.8) | 0.56 (0.53, 0.6) | 0.68 (0.63, 0.73) | 0.58 (0.57, 0.6) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.119 (0.112, 0.127) | 0.045 (0.044, 0.046) | 0.051 (0.043, 0.059) | 0.02 (0.004, 0.037) | 0.033 (0.007, 0.06) | 0 (0, 0) | 0.13 (0.074, 0.185) | 0.074 (0.069, 0.078) | ||||||||||
| Taxel_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | ||||||||||
| n | 1 (1, 1) | 19 (19, 19) | 2 (2, 2) | 0 (0, 0) | 2 (2, 2) | 6 (6, 6) | 1 (1, 1) | 0 (0, 0) | ||||||||||
| post_p | 0.73 (0.73, 0.73) | 0.82 (0.82, 0.82) | 0.6 (0.6, 0.6) | NA (NA, NA) | 0.63 (0.63, 0.63) | 0.77 (0.77, 0.77) | 0.61 (0.61, 0.61) | NA (NA, NA) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0 (0, 0) | 0.031 (0.031, 0.031) | 0 (0, 0) | NA (NA, NA) | 0.169 (0.169, 0.169) | 0.163 (0.163, 0.163) | 0 (0, 0) | NA (NA, NA) | ||||||||||
| TP53- & AR- | Carboplatin | count | 24 | 24 | 24 | 24 | ||||||||||||
| time | 15 (10, 27) | 15 (10, 27) | 15 (10, 27) | 15 (10, 27) | ||||||||||||||
| n | 19 (10, 42) | 4 (0, 12) | 6 (4, 12) | 6 (2, 11) | ||||||||||||||
| post_p | 0.81 (0.71, 0.92) | 0.69 (0.59, 0.85) | 0.78 (0.53, 0.91) | 0.71 (0.52, 0.85) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.07 (0.027, 0.095) | 0.056 (0, 0.109) | 0.068 (0.033, 0.142) | 0.08 (0.039, 0.147) | ||||||||||||||
| Hormone_therapies | count | 50 | 50 | 50 | 50 | |||||||||||||
| time | 10 (6, 21) | 10 (6, 21) | 10 (6, 21) | 10 (6, 21) | ||||||||||||||
| n | 26 (21, 50) | 4 (2, 8) | 1 (0, 5) | 1 (0, 10) | ||||||||||||||
| post_p | 0.85 (0.74, 0.92) | 0.69 (0.55, 0.83) | 0.57 (0.51, 0.72) | 0.54 (0.52, 0.8) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.081 (0.051, 0.097) | 0.062 (0, 0.126) | 0 (0, 0.095) | 0 (0, 0.106) | ||||||||||||||
| Niraparib | count | 22 | 22 | 22 | 22 | |||||||||||||
| time | 14 (9, 21) | 14 (9, 21) | 14 (9, 21) | 14 (9, 21) | ||||||||||||||
| n | 18 (12, 34) | 2 (0, 6) | 6 (3, 11) | 5 (3, 11) | ||||||||||||||
| post_p | 0.8 (0.73, 0.9) | 0.61 (0.52, 0.82) | 0.78 (0.59, 0.89) | 0.72 (0.54, 0.88) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.07 (0.028, 0.083) | 0.036 (0, 0.108) | 0.061 (0.003, 0.115) | 0.075 (0.002, 0.106) | ||||||||||||||
| Taxel_therapies | count | 44 | 44 | 44 | 44 | |||||||||||||
| time | 14 (9, 27) | 14 (9, 27) | 14 (9, 27) | 14 (9, 27) | ||||||||||||||
| n | 22 (18, 39) | 5 (1, 12) | 3 (1, 12) | 3 (0, 8) | ||||||||||||||
| post_p | 0.83 (0.72, 0.96) | 0.73 (0.53, 0.89) | 0.62 (0.52, 0.83) | 0.67 (0.52, 0.86) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.076 (0.037, 0.099) | 0.065 (0, 0.122) | 0.057 (0, 0.113) | 0.058 (0, 0.141) | ||||||||||||||
| TP53+ | Carboplatin | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||
| time | 12 (10, 13) | 12 (10, 13) | 12 (10, 13) | 12 (10, 13) | 12 (10, 13) | 12 (10, 13) | 12 (10, 13) | 12 (10, 13) | ||||||||||
| n | 12 (6, 17) | 4 (3, 4) | 3 (2, 5) | 5 (1, 5) | 2 (1, 5) | 1 (0, 3) | 1 (1, 2) | 4 (2, 5) | ||||||||||
| post_p | 0.78 (0.58, 0.82) | 0.57 (0.53, 0.67) | 0.57 (0.54, 0.58) | 0.84 (0.74, 0.95) | 0.72 (0.61, 0.75) | 0.53 (0.51, 0.54) | 0.64 (0.55, 0.67) | 0.61 (0.56, 0.82) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.053 (0.022, 0.154) | 0.071 (0.067, 0.073) | 0.081 (0.059, 0.153) | 0.03 (0.024, 0.036) | 0.092 (0.018, 0.101) | 0.056 (0.011, 0.102) | 0.099 (0.02, 0.11) | 0 (0, 0.104) | ||||||||||
| Hormone_therapies | count | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | |||||||||
| time | 10 (7, 14) | 10 (7, 14) | 10 (7, 14) | 10 (7, 14) | 10 (7, 14) | 10 (7, 14) | 10 (7, 14) | 10 (7, 14) | ||||||||||
| n | 15 (11, 18) | 6 (2, 11) | 0 (0, 3) | 1 (0, 4) | 2 (0, 5) | 3 (0, 5) | 0 (0, 3) | 1 (0, 2) | ||||||||||
| post_p | 0.8 (0.71, 0.88) | 0.75 (0.56, 0.86) | 0.55 (0.52, 0.64) | 0.59 (0.53, 0.69) | 0.7 (0.58, 0.76) | 0.61 (0.55, 0.73) | 0.62 (0.56, 0.73) | 0.61 (0.55, 0.79) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.077 (0.043, 0.108) | 0.064 (0, 0.102) | 0 (0, 0.041) | 0 (0, 0.087) | 0 (0, 0.088) | 0.032 (0, 0.121) | 0 (0, 0.151) | 0 (0, 0.031) | ||||||||||
| Niraparib | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |||||||||
| time | 11 (10, 12) | 11 (10, 12) | 11 (10, 12) | 11 (10, 12) | 11 (10, 12) | 11 (10, 12) | 11 (10, 12) | 11 (10, 12) | ||||||||||
| n | 15 (10, 20) | 2 (2, 3) | 4 (4, 5) | 3 (2, 4) | 4 (3, 5) | 2 (1, 2) | 4 (2, 5) | 5 (3, 7) | ||||||||||
| post_p | 0.76 (0.72, 0.8) | 0.64 (0.59, 0.69) | 0.64 (0.58, 0.71) | 0.57 (0.52, 0.62) | 0.7 (0.7, 0.7) | 0.56 (0.53, 0.59) | 0.55 (0.54, 0.56) | 0.76 (0.74, 0.78) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.069 (0.068, 0.07) | 0 (0, 0) | 0.08 (0.072, 0.088) | 0.122 (0.094, 0.15) | 0.031 (0.006, 0.055) | 0 (0, 0) | 0.119 (0.102, 0.136) | 0.027 (0.005, 0.049) | ||||||||||
| Taxel_therapies | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |||||||||
| time | 10 (8, 13) | 10 (8, 13) | 10 (8, 13) | 10 (8, 13) | 10 (8, 13) | 10 (8, 13) | 10 (8, 13) | 10 (8, 13) | ||||||||||
| n | 11 (10, 13) | 12 (8, 18) | 2 (0, 3) | 0 (0, 1) | 2 (1, 3) | 4 (3, 6) | 1 (1, 2) | 2 (0, 3) | ||||||||||
| post_p | 0.78 (0.72, 0.84) | 0.83 (0.76, 0.88) | 0.55 (0.53, 0.7) | 0.56 (0.56, 0.56) | 0.57 (0.52, 0.66) | 0.68 (0.53, 0.78) | 0.67 (0.56, 0.68) | 0.6 (0.53, 0.65) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.07 (0.016, 0.093) | 0.066 (0.044, 0.07) | 0 (0, 0.028) | 0 (0, 0) | 0.074 (0, 0.177) | 0.098 (0.057, 0.149) | 0 (0, 0.297) | 0 (0, 0.07) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Carboplatin | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| time | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | ||
| n | 5 (5, 5) | 2 (2, 2) | 6 (6, 6) | 3 (3, 3) | 0 (0, 0) | 1 (1, 1) | 2 (2, 2) | 2 (2, 2) | 5 (5, 5) | 0 (0, 0) | 2 (2, 2) | 2 (2, 2) | 4 (4, 4) | 3 (3, 3) | 0 (0, 0) | 1 (1, 1) | ||
| post_p | 0.28 (0.28, 0.28) | 0.38 (0.38, 0.38) | 0.28 (0.28, 0.28) | 0.43 (0.43, 0.43) | NA (NA, NA) | 0.23 (0.23, 0.23) | 0.21 (0.21, 0.21) | 0.27 (0.27, 0.27) | 0.35 (0.35, 0.35) | NA (NA, NA) | 0.36 (0.36, 0.36) | 0.47 (0.47, 0.47) | 0.4 (0.4, 0.4) | 0.38 (0.38, 0.38) | NA (NA, NA) | 0.47 (0.47, 0.47) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.248 (0.248, 0.248) | 0.269 (0.269, 0.269) | 0.179 (0.179, 0.179) | 0.164 (0.164, 0.164) | NA (NA, NA) | 2.439 (2.439, 2.439) | 1.674 (1.674, 1.674) | 0.9 (0.9, 0.9) | 0.192 (0.192, 0.192) | NA (NA, NA) | 0.32 (0.32, 0.32) | 0.335 (0.335, 0.335) | 0.153 (0.153, 0.153) | 0.083 (0.083, 0.083) | NA (NA, NA) | 0 (0, 0) | ||
| Hormone_therapies | count | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | |
| time | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | ||
| n | 15 (12, 19) | 2 (0, 5) | 6 (4, 11) | 2 (2, 5) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 1 (0, 3) | 1 (0, 2) | 0 (0, 3) | 1 (0, 4) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | ||
| post_p | 0.29 (0.18, 0.47) | 0.39 (0.32, 0.45) | 0.25 (0.14, 0.37) | 0.38 (0.29, 0.47) | 0.39 (0.27, 0.49) | 0.29 (0.29, 0.29) | 0.28 (0.25, 0.32) | 0.4 (0.4, 0.4) | 0.48 (0.39, 0.49) | 0.3 (0.26, 0.4) | 0.31 (0.27, 0.35) | 0.4 (0.28, 0.47) | 0.35 (0.31, 0.4) | 0.42 (0.42, 0.42) | 0.43 (0.4, 0.47) | 0.28 (0.28, 0.28) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.162 (0.096, 0.21) | 0.244 (0.115, 0.427) | 0.204 (0.077, 0.398) | 0.19 (0.114, 1.114) | 0.067 (0, 0.682) | 0.356 (0.356, 0.356) | 0.433 (0.087, 0.945) | 0.098 (0.02, 0.177) | 0.151 (0, 0.439) | 0.463 (0.193, 0.988) | 0.114 (0, 0.537) | 0 (0, 0.214) | 3.829 (0.863, 6.794) | 0.351 (0.351, 0.351) | 0.087 (0.017, 0.157) | 0 (0, 0.291) | ||
| Niraparib | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |
| time | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | ||
| n | 4 (3, 4) | 2 (0, 3) | 7 (6, 8) | 2 (0, 3) | 4 (2, 5) | 6 (5, 7) | 3 (1, 5) | 1 (1, 1) | 0 (0, 1) | 2 (1, 3) | 0 (0, 1) | 1 (0, 2) | 2 (1, 2) | 4 (4, 4) | 4 (2, 6) | 0 (0, 1) | ||
| post_p | 0.37 (0.33, 0.41) | 0.24 (0.24, 0.24) | 0.28 (0.13, 0.42) | 0.16 (0.16, 0.16) | 0.36 (0.31, 0.41) | 0.35 (0.35, 0.36) | 0.39 (0.39, 0.39) | 0.33 (0.33, 0.33) | 0.32 (0.32, 0.32) | 0.36 (0.34, 0.38) | 0.46 (0.46, 0.46) | 0.44 (0.44, 0.44) | 0.26 (0.24, 0.28) | 0.36 (0.34, 0.37) | 0.37 (0.34, 0.4) | 0.45 (0.45, 0.45) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.228 (0.225, 0.23) | 0.52 (0.52, 0.52) | 0.164 (0.142, 0.185) | 0.283 (0.283, 0.283) | 0.366 (0.177, 0.555) | 0.137 (0.117, 0.157) | 0.103 (0.103, 0.103) | 0.294 (0.226, 0.361) | 0.733 (0.733, 0.733) | 2.82 (0.687, 4.954) | 0.293 (0.293, 0.293) | 0 (0, 0) | 1.243 (0.446, 2.039) | 0.164 (0.152, 0.177) | 4.739 (1.034, 8.444) | 0.143 (0.143, 0.143) | ||
| Taxel_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| time | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | ||
| n | 6 (6, 6) | 1 (1, 1) | 3 (3, 3) | 6 (6, 6) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 1 (1, 1) | 2 (2, 2) | 4 (4, 4) | 4 (4, 4) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| post_p | 0.48 (0.48, 0.48) | 0.46 (0.46, 0.46) | 0.44 (0.44, 0.44) | 0.32 (0.32, 0.32) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.44 (0.44, 0.44) | 0.5 (0.5, 0.5) | 0.43 (0.43, 0.43) | 0.28 (0.28, 0.28) | 0.33 (0.33, 0.33) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.118 (0.118, 0.118) | 0 (0, 0) | 0.183 (0.183, 0.183) | 0.228 (0.228, 0.228) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0.167 (0.167, 0.167) | 0.178 (0.178, 0.178) | 0.145 (0.145, 0.145) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||
| DRD+ | Carboplatin | count | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | ||||||||
| time | 24 (16, 33) | 24 (16, 33) | 24 (16, 33) | 24 (16, 33) | 24 (16, 33) | 24 (16, 33) | 24 (16, 33) | 24 (16, 33) | ||||||||||
| n | 7 (1, 15) | 6 (2, 11) | 2 (0, 7) | 3 (2, 6) | 4 (1, 7) | 3 (1, 7) | 5 (2, 10) | 4 (2, 7) | ||||||||||
| post_p | 0.4 (0.25, 0.46) | 0.39 (0.18, 0.46) | 0.3 (0.24, 0.46) | 0.34 (0.2, 0.45) | 0.38 (0.28, 0.45) | 0.36 (0.2, 0.45) | 0.33 (0.24, 0.47) | 0.37 (0.24, 0.49) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.163 (0.122, 0.331) | 0.149 (0.107, 0.4) | 0.207 (0.124, 0.577) | 0.207 (0.112, 0.431) | 0.189 (0.121, 0.809) | 0.196 (0.14, 1.101) | 0.183 (0.093, 0.425) | 0.189 (0.135, 0.343) | ||||||||||
| Hormone_therapies | count | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | |||||||||
| time | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | ||||||||||
| n | 4 (2, 19) | 4 (2, 7) | 4 (2, 9) | 4 (2, 8) | 3 (2, 6) | 3 (2, 6) | 3 (0, 8) | 3 (2, 5) | ||||||||||
| post_p | 0.38 (0.19, 0.49) | 0.28 (0.13, 0.45) | 0.32 (0.25, 0.45) | 0.4 (0.3, 0.45) | 0.33 (0.25, 0.46) | 0.33 (0.18, 0.44) | 0.35 (0.2, 0.45) | 0.37 (0.18, 0.48) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.142 (0.108, 0.34) | 0.188 (0.129, 0.591) | 0.157 (0.115, 0.428) | 0.165 (0.097, 0.615) | 0.186 (0.133, 0.281) | 0.217 (0.14, 0.334) | 0.18 (0.142, 0.4) | 0.191 (0.144, 0.38) | ||||||||||
| Niraparib | count | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | |||||||||
| time | 23 (16, 36) | 23 (16, 36) | 23 (16, 36) | 23 (16, 36) | 23 (16, 36) | 23 (16, 36) | 23 (16, 36) | 23 (16, 36) | ||||||||||
| n | 6 (3, 12) | 5 (2, 12) | 4 (2, 8) | 3 (1, 9) | 3 (2, 8) | 3 (2, 7) | 3 (2, 11) | 4 (1, 9) | ||||||||||
| post_p | 0.38 (0.13, 0.48) | 0.34 (0.2, 0.47) | 0.34 (0.22, 0.49) | 0.33 (0.14, 0.48) | 0.33 (0.16, 0.49) | 0.36 (0.16, 0.45) | 0.36 (0.22, 0.47) | 0.35 (0.21, 0.48) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.161 (0.102, 0.347) | 0.164 (0.117, 0.312) | 0.174 (0.1, 0.541) | 0.196 (0.109, 0.623) | 0.186 (0.094, 0.75) | 0.169 (0.122, 0.38) | 0.197 (0.085, 0.368) | 0.18 (0.127, 0.524) | ||||||||||
| Taxel_therapies | count | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | |||||||||
| time | 28 (22, 33) | 28 (22, 33) | 28 (22, 33) | 28 (22, 33) | 28 (22, 33) | 28 (22, 33) | 28 (22, 33) | 28 (22, 33) | ||||||||||
| n | 6 (2, 13) | 3 (1, 12) | 3 (1, 7) | 4 (1, 6) | 4 (1, 7) | 4 (1, 6) | 3 (2, 7) | 2 (1, 5) | ||||||||||
| post_p | 0.41 (0.23, 0.48) | 0.37 (0.2, 0.48) | 0.35 (0.24, 0.48) | 0.35 (0.12, 0.46) | 0.35 (0.23, 0.47) | 0.35 (0.18, 0.47) | 0.37 (0.2, 0.47) | 0.34 (0.19, 0.46) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.159 (0.107, 0.344) | 0.176 (0.113, 2.086) | 0.174 (0.093, 0.543) | 0.208 (0.119, 0.684) | 0.179 (0.116, 0.516) | 0.228 (0.128, 0.618) | 0.168 (0.114, 0.376) | 0.212 (0.123, 0.473) | ||||||||||
| TEfus+ | Carboplatin | count | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | ||||||||
| time | 20 (13, 33) | 20 (13, 33) | 20 (13, 33) | 20 (13, 33) | 20 (13, 33) | 20 (13, 33) | 20 (13, 33) | 20 (13, 33) | ||||||||||
| n | 4 (2, 8) | 8 (2, 15) | 5 (3, 8) | 3 (1, 6) | 3 (1, 9) | 3 (1, 10) | 3 (1, 6) | 4 (3, 7) | ||||||||||
| post_p | 0.36 (0.19, 0.44) | 0.32 (0.14, 0.45) | 0.4 (0.2, 0.48) | 0.38 (0.2, 0.49) | 0.36 (0.27, 0.48) | 0.37 (0.24, 0.49) | 0.35 (0.19, 0.46) | 0.37 (0.18, 0.47) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.182 (0.111, 0.323) | 0.175 (0.113, 0.622) | 0.161 (0.1, 0.307) | 0.151 (0.091, 3.734) | 0.173 (0.124, 0.364) | 0.162 (0.1, 0.734) | 0.172 (0.141, 0.523) | 0.168 (0.117, 0.366) | ||||||||||
| Hormone_therapies | count | 29 | 29 | 29 | 29 | 29 | 29 | 29 | 29 | |||||||||
| time | 25 (18, 35) | 25 (18, 35) | 25 (18, 35) | 25 (18, 35) | 25 (18, 35) | 25 (18, 35) | 25 (18, 35) | 25 (18, 35) | ||||||||||
| n | 5 (2, 11) | 8 (5, 20) | 2 (0, 6) | 3 (1, 7) | 3 (1, 8) | 4 (2, 7) | 2 (1, 7) | 2 (1, 4) | ||||||||||
| post_p | 0.35 (0.21, 0.48) | 0.31 (0.12, 0.44) | 0.35 (0.24, 0.46) | 0.37 (0.19, 0.48) | 0.31 (0.19, 0.45) | 0.37 (0.21, 0.48) | 0.35 (0.18, 0.47) | 0.35 (0.26, 0.48) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.177 (0.11, 0.494) | 0.142 (0.116, 0.284) | 0.212 (0.113, 0.916) | 0.206 (0.106, 0.467) | 0.226 (0.118, 0.726) | 0.177 (0.123, 0.447) | 0.223 (0.118, 0.585) | 0.234 (0.111, 0.376) | ||||||||||
| Niraparib | count | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | |||||||||
| time | 24 (14, 36) | 24 (14, 36) | 24 (14, 36) | 24 (14, 36) | 24 (14, 36) | 24 (14, 36) | 24 (14, 36) | 24 (14, 36) | ||||||||||
| n | 5 (2, 12) | 6 (2, 24) | 5 (2, 16) | 3 (1, 8) | 4 (1, 10) | 3 (1, 7) | 4 (2, 8) | 3 (1, 6) | ||||||||||
| post_p | 0.35 (0.21, 0.47) | 0.38 (0.19, 0.49) | 0.32 (0.17, 0.45) | 0.33 (0.19, 0.47) | 0.37 (0.21, 0.48) | 0.41 (0.24, 0.49) | 0.33 (0.19, 0.46) | 0.34 (0.18, 0.48) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.159 (0.116, 0.302) | 0.125 (0.109, 0.365) | 0.16 (0.117, 0.402) | 0.176 (0.1, 0.46) | 0.152 (0.087, 1.138) | 0.167 (0.105, 0.36) | 0.176 (0.113, 0.359) | 0.18 (0.129, 0.467) | ||||||||||
| Taxel_therapies | count | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | |||||||||
| time | 22 (11, 32) | 22 (11, 32) | 22 (11, 32) | 22 (11, 32) | 22 (11, 32) | 22 (11, 32) | 22 (11, 32) | 22 (11, 32) | ||||||||||
| n | 6 (5, 11) | 10 (6, 27) | 3 (1, 8) | 1 (0, 4) | 5 (2, 10) | 5 (2, 10) | 1 (0, 3) | 2 (0, 6) | ||||||||||
| post_p | 0.36 (0.14, 0.49) | 0.36 (0.17, 0.46) | 0.37 (0.21, 0.45) | 0.35 (0.16, 0.43) | 0.35 (0.19, 0.47) | 0.37 (0.23, 0.49) | 0.31 (0.24, 0.44) | 0.32 (0.23, 0.47) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.148 (0.103, 0.218) | 0.146 (0.112, 0.181) | 0.189 (0.125, 0.733) | 0.298 (0.151, 3.27) | 0.161 (0.105, 0.32) | 0.15 (0.097, 0.218) | 0.299 (0.093, 0.925) | 0.193 (0.102, 0.365) | ||||||||||
| TP53- & AR- | Carboplatin | count | 128 | 128 | 128 | 128 | ||||||||||||
| time | 22 (14, 34) | 22 (14, 34) | 22 (14, 34) | 22 (14, 34) | ||||||||||||||
| n | 18 (7, 52) | 4 (1, 11) | 7 (2, 13) | 6 (2, 13) | ||||||||||||||
| post_p | 0.35 (0.11, 0.47) | 0.34 (0.19, 0.48) | 0.36 (0.2, 0.47) | 0.34 (0.16, 0.48) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.128 (0.107, 0.25) | 0.165 (0.108, 0.666) | 0.156 (0.108, 0.328) | 0.159 (0.104, 0.6) | ||||||||||||||
| Hormone_therapies | count | 161 | 161 | 161 | 161 | |||||||||||||
| time | 15 (8, 32) | 15 (8, 32) | 15 (8, 32) | 15 (8, 32) | ||||||||||||||
| n | 25 (17, 54) | 5 (2, 10) | 3 (0, 8) | 3 (1, 8) | ||||||||||||||
| post_p | 0.33 (0.14, 0.46) | 0.36 (0.17, 0.48) | 0.38 (0.21, 0.48) | 0.37 (0.2, 0.49) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.126 (0.105, 0.16) | 0.175 (0.1, 0.439) | 0.171 (0.102, 0.509) | 0.175 (0.099, 0.553) | ||||||||||||||
| Niraparib | count | 119 | 119 | 119 | 119 | |||||||||||||
| time | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | ||||||||||||||
| n | 22 (8, 57) | 4 (1, 10) | 7 (3, 14) | 6 (2, 13) | ||||||||||||||
| post_p | 0.35 (0.11, 0.47) | 0.36 (0.21, 0.47) | 0.36 (0.15, 0.48) | 0.35 (0.13, 0.47) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.127 (0.101, 0.188) | 0.162 (0.11, 0.517) | 0.144 (0.101, 0.457) | 0.156 (0.106, 0.422) | ||||||||||||||
| Taxel_therapies | count | 116 | 116 | 116 | 116 | |||||||||||||
| time | 22 (15, 33) | 22 (15, 33) | 22 (15, 33) | 22 (15, 33) | ||||||||||||||
| n | 19 (9, 52) | 6 (2, 14) | 5 (2, 10) | 4 (2, 10) | ||||||||||||||
| post_p | 0.29 (0.07, 0.45) | 0.35 (0.16, 0.47) | 0.37 (0.17, 0.48) | 0.36 (0.21, 0.48) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.135 (0.106, 0.207) | 0.144 (0.103, 0.347) | 0.164 (0.106, 0.529) | 0.153 (0.104, 0.44) | ||||||||||||||
| TP53+ | Carboplatin | count | 32 | 32 | 32 | 32 | 32 | 32 | 32 | 32 | ||||||||
| time | 22 (14, 34) | 22 (14, 34) | 22 (14, 34) | 22 (14, 34) | 22 (14, 34) | 22 (14, 34) | 22 (14, 34) | 22 (14, 34) | ||||||||||
| n | 13 (4, 29) | 7 (2, 14) | 3 (1, 7) | 3 (1, 8) | 5 (2, 11) | 4 (1, 7) | 4 (2, 7) | 4 (1, 9) | ||||||||||
| post_p | 0.35 (0.1, 0.46) | 0.35 (0.14, 0.46) | 0.34 (0.18, 0.47) | 0.36 (0.16, 0.45) | 0.4 (0.23, 0.48) | 0.33 (0.15, 0.48) | 0.37 (0.23, 0.48) | 0.39 (0.22, 0.47) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.137 (0.104, 0.325) | 0.147 (0.109, 0.434) | 0.19 (0.099, 0.622) | 0.191 (0.097, 0.948) | 0.144 (0.109, 0.357) | 0.192 (0.115, 0.343) | 0.166 (0.098, 0.427) | 0.168 (0.093, 0.31) | ||||||||||
| Hormone_therapies | count | 38 | 38 | 38 | 38 | 38 | 38 | 38 | 38 | |||||||||
| time | 20 (10, 28) | 20 (10, 28) | 20 (10, 28) | 20 (10, 28) | 20 (10, 28) | 20 (10, 28) | 20 (10, 28) | 20 (10, 28) | ||||||||||
| n | 16 (9, 36) | 7 (2, 19) | 2 (0, 4) | 2 (0, 6) | 4 (1, 7) | 3 (1, 5) | 2 (0, 6) | 2 (1, 4) | ||||||||||
| post_p | 0.32 (0.09, 0.47) | 0.32 (0.12, 0.48) | 0.35 (0.22, 0.47) | 0.36 (0.19, 0.48) | 0.36 (0.25, 0.48) | 0.34 (0.17, 0.46) | 0.38 (0.29, 0.44) | 0.4 (0.27, 0.48) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.129 (0.103, 0.182) | 0.149 (0.109, 0.614) | 0.212 (0.099, 0.94) | 0.209 (0.102, 0.923) | 0.184 (0.101, 1.892) | 0.21 (0.111, 0.478) | 0.205 (0.099, 0.758) | 0.202 (0.087, 0.348) | ||||||||||
| Niraparib | count | 31 | 31 | 31 | 31 | 31 | 31 | 31 | 31 | |||||||||
| time | 22 (13, 33) | 22 (13, 33) | 22 (13, 33) | 22 (13, 33) | 22 (13, 33) | 22 (13, 33) | 22 (13, 33) | 22 (13, 33) | ||||||||||
| n | 9 (3, 26) | 9 (4, 23) | 4 (1, 7) | 3 (2, 6) | 4 (1, 8) | 2 (1, 9) | 5 (2, 7) | 4 (1, 9) | ||||||||||
| post_p | 0.28 (0.15, 0.41) | 0.32 (0.16, 0.48) | 0.36 (0.23, 0.47) | 0.33 (0.15, 0.48) | 0.34 (0.18, 0.45) | 0.36 (0.18, 0.46) | 0.43 (0.19, 0.49) | 0.35 (0.17, 0.48) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.14 (0.115, 0.371) | 0.155 (0.107, 0.335) | 0.172 (0.106, 0.387) | 0.202 (0.125, 0.425) | 0.187 (0.124, 0.404) | 0.255 (0.118, 0.856) | 0.126 (0.09, 0.344) | 0.195 (0.117, 0.63) | ||||||||||
| Taxel_therapies | count | 33 | 33 | 33 | 33 | 33 | 33 | 33 | 33 | |||||||||
| time | 18 (10, 29) | 18 (10, 29) | 18 (10, 29) | 18 (10, 29) | 18 (10, 29) | 18 (10, 29) | 18 (10, 29) | 18 (10, 29) | ||||||||||
| n | 10 (4, 36) | 10 (5, 18) | 1 (0, 5) | 2 (0, 7) | 4 (1, 8) | 5 (1, 10) | 2 (0, 6) | 3 (1, 5) | ||||||||||
| post_p | 0.35 (0.21, 0.46) | 0.33 (0.15, 0.45) | 0.4 (0.25, 0.49) | 0.38 (0.2, 0.48) | 0.39 (0.23, 0.49) | 0.36 (0.2, 0.48) | 0.36 (0.19, 0.49) | 0.32 (0.19, 0.48) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.131 (0.111, 0.215) | 0.133 (0.092, 0.191) | 0.214 (0.088, 0.673) | 0.212 (0.09, 0.814) | 0.159 (0.112, 0.318) | 0.145 (0.081, 0.455) | 0.206 (0.139, 1) | 0.202 (0.081, 0.791) |