Simulation scenario 1

Setting description

treatments equally effective across the biomarker signatures

Simulations setting

PFS distributions

Treatment effects

By subgroup:

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

By signature:

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 11 4 1 1 TP53- & AR- 50 44 24 22 TP53+ 14 4 3 2 DRD+ 3 1 2 2 TEfus+ 3 1 4 2

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.022 0.008 0.002 0.002 TP53- & AR- 0.100 0.088 0.048 0.044 TP53+ 0.028 0.008 0.006 0.004 DRD+ 0.006 0.002 0.004 0.004 TEfus+ 0.006 0.002 0.008 0.004

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 11 1 1 2 TP53- & AR- 161 116 128 119 TP53+ 38 33 32 31 DRD+ 16 18 15 25 TEfus+ 29 24 17 26

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.022 0.002 0.002 0.004 TP53- & AR- 0.322 0.232 0.256 0.238 TP53+ 0.076 0.066 0.064 0.062 DRD+ 0.032 0.036 0.030 0.050 TEfus+ 0.058 0.048 0.034 0.052

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 17 13 12 18 TP53+ 7 12 6 8 DRD+ 0 0 0 0 TEfus+ 0 2 1 0

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.034 0.026 0.024 0.036 TP53+ 0.014 0.024 0.012 0.016 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.004 0.002 0.000

Errors & power

The overall error was 0.344.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.152             0.102             0.066             0.058 

The overall power was .
The corresponding power separate for the different treatments were:

NULL

Median results at the end of the trial

By signature:

signature	var	Carboplatin	Control	Hormone_therapies	Niraparib	Taxel_therapies
all	graduation	1	0	11	1	4
	futility	1	0	11	2	1
	max_n	0	0	0	0	0
	n	186 (130, 258)	420 (386, 456)	182 (119, 249)	188 (132, 255)	196 (133, 252)
	n_unique	170 (117, 237)	385 (354, 418)	166 (108, 231)	170 (118, 235)	179 (120, 234)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	6 (6, 7)	NA (NA, NA)	4 (3, 6)	7 (7, 15)	5 (4, 10)
	post_p	0.45 (0.1, 0.87)	NA (NA, NA)	0.48 (0.08, 0.87)	0.47 (0.08, 0.89)	0.51 (0.09, 0.89)
	rate	0.113 (0.102, 0.126)	0.112 (0.104, 0.12)	0.113 (0.101, 0.127)	0.113 (0.102, 0.126)	0.112 (0.101, 0.127)
DRD+	graduation	2	0	3	2	1
	futility	15	0	16	25	18
	max_n	0	0	0	0	0
	n	62 (43, 85)	114 (98, 129)	45 (25, 66)	62 (42, 85)	49 (30, 68)
	n_unique	56 (38, 78)	103 (89, 119)	41 (23, 60)	56 (36, 77)	44 (27, 62)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	24 (14, 32)	NA (NA, NA)	30 (19, 34)	22 (14, 35)	28 (17, 32)
	post_p	0.48 (0.1, 0.85)	NA (NA, NA)	0.49 (0.11, 0.85)	0.46 (0.11, 0.86)	0.52 (0.13, 0.88)
	rate	0.114 (0.098, 0.14)	0.112 (0.098, 0.129)	0.114 (0.091, 0.148)	0.114 (0.096, 0.138)	0.11 (0.092, 0.14)
TEfus+	graduation	4	0	3	2	1
	futility	17	0	29	26	24
	max_n	1	0	0	0	2
	n	71 (46, 100)	152 (136, 173)	66 (33, 96)	71 (47, 98)	79 (50, 104)
	n_unique	65 (42, 92)	139 (123, 159)	60 (30, 86)	64 (42, 89)	72 (46, 96)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	18 (11, 33)	NA (NA, NA)	24 (15, 35)	24 (14, 35)	22 (10, 32)
	post_p	0.47 (0.1, 0.87)	NA (NA, NA)	0.49 (0.1, 0.86)	0.47 (0.09, 0.88)	0.52 (0.1, 0.88)
	rate	0.114 (0.097, 0.139)	0.112 (0.1, 0.125)	0.114 (0.095, 0.142)	0.113 (0.097, 0.139)	0.112 (0.096, 0.134)
TP53- & AR-	graduation	24	0	50	22	44
	futility	128	0	161	119	116
	max_n	12	0	17	18	13
	n	70 (29, 130)	176 (152, 199)	63 (26, 128)	70 (29, 128)	65 (27, 122)
	n_unique	64 (26, 122)	162 (138, 185)	58 (25, 121)	64 (27, 120)	59 (24, 114)
	time_trial	36 (18, 36)	36 (36, 36)	36 (9, 36)	36 (19, 36)	36 (17, 36)
	time_stop	21 (12, 33)	NA (NA, NA)	13 (7, 31)	21 (13, 32)	20 (11, 32)
	post_p	0.45 (0.1, 0.88)	NA (NA, NA)	0.45 (0.11, 0.86)	0.45 (0.1, 0.88)	0.47 (0.08, 0.91)
	rate	0.115 (0.097, 0.143)	0.112 (0.1, 0.124)	0.115 (0.098, 0.141)	0.114 (0.098, 0.141)	0.114 (0.094, 0.144)
TP53+	graduation	3	0	14	2	4
	futility	32	0	38	31	33
	max_n	6	0	7	8	12
	n	86 (52, 123)	186 (163, 207)	86 (39, 123)	84 (54, 122)	91 (55, 131)
	n_unique	78 (47, 113)	169 (148, 188)	79 (37, 113)	76 (48, 110)	82 (50, 120)
	time_trial	36 (36, 36)	36 (36, 36)	36 (30, 36)	36 (36, 36)	36 (36, 36)
	time_stop	21 (12, 34)	NA (NA, NA)	18 (8, 28)	22 (12, 33)	17 (10, 29)
	post_p	0.48 (0.09, 0.87)	NA (NA, NA)	0.47 (0.1, 0.9)	0.48 (0.09, 0.89)	0.5 (0.1, 0.89)
	rate	0.113 (0.098, 0.137)	0.111 (0.101, 0.126)	0.113 (0.096, 0.133)	0.114 (0.097, 0.134)	0.113 (0.098, 0.133)

By subgroup combinations:

subtype	var	Carboplatin	Control	Hormone_therapies	Niraparib	Taxel_therapies
—-	graduation	154	0	232	144	165
	futility	0	0	0	0	0
	max_n	12	0	17	18	13
	n	37 (10, 89)	111 (91, 132)	35 (17, 93)	33 (10, 91)	32 (10, 87)
	n_unique	34 (9, 84)	103 (84, 124)	33 (16, 91)	31 (9, 86)	30 (8, 84)
	post_p	0.45 (0.11, 0.89)	NA (NA, NA)	0.45 (0.11, 0.86)	0.44 (0.1, 0.85)	0.44 (0.08, 0.88)
	rate	0.115 (0.093, 0.181)	0.112 (0.099, 0.128)	0.117 (0.096, 0.154)	0.117 (0.095, 0.174)	0.118 (0.093, 0.186)
—+	graduation	169	0	239	154	180
	futility	0	0	0	0	0
	max_n	13	0	17	18	15
	n	8 (2, 19)	21 (14, 28)	7 (2, 20)	7 (2, 18)	9 (3, 22)
	n_unique	6 (1, 17)	19 (13, 26)	6 (2, 19)	6 (2, 16)	8 (2, 21)
	post_p	0.44 (0.19, 0.82)	NA (NA, NA)	0.48 (0.19, 0.84)	0.42 (0.18, 0.83)	0.47 (0.18, 0.85)
	rate	0.128 (0.078, 0.338)	0.113 (0.084, 0.159)	0.12 (0.077, 0.276)	0.131 (0.078, 0.333)	0.125 (0.079, 0.235)
–+-	graduation	37	0	71	35	42
	futility	0	0	0	0	0
	max_n	6	0	7	8	12
	n	23 (7, 54)	63 (49, 77)	26 (10, 58)	23 (5, 54)	23 (7, 53)
	n_unique	21 (6, 51)	57 (44, 72)	25 (9, 54)	21 (5, 50)	21 (6, 49)
	post_p	0.42 (0.11, 0.84)	NA (NA, NA)	0.45 (0.12, 0.86)	0.42 (0.11, 0.86)	0.42 (0.12, 0.86)
	rate	0.121 (0.09, 0.223)	0.113 (0.094, 0.134)	0.119 (0.091, 0.173)	0.118 (0.089, 0.238)	0.121 (0.091, 0.206)
–++	graduation	55	0	92	60	60
	futility	0	0	0	0	0
	max_n	7	0	7	8	14
	n	14 (4, 35)	42 (32, 52)	15 (4, 35)	16 (4, 35)	22 (7, 43)
	n_unique	12 (3, 32)	37 (29, 48)	14 (4, 33)	15 (4, 32)	19 (7, 40)
	post_p	0.43 (0.14, 0.83)	NA (NA, NA)	0.44 (0.14, 0.83)	0.45 (0.15, 0.85)	0.46 (0.12, 0.88)
	rate	0.124 (0.086, 0.26)	0.111 (0.091, 0.142)	0.121 (0.084, 0.228)	0.12 (0.086, 0.242)	0.117 (0.088, 0.191)
-+–	graduation	162	0	239	160	175
	futility	0	0	0	0	0
	max_n	12	0	17	17	13
	n	10 (3, 21)	21 (15, 28)	5 (0, 17)	10 (3, 21)	7 (2, 18)
	n_unique	8 (3, 20)	19 (13, 26)	4 (0, 16)	9 (3, 20)	6 (2, 16)
	post_p	0.44 (0.18, 0.84)	NA (NA, NA)	0.48 (0.2, 0.84)	0.46 (0.17, 0.87)	0.48 (0.18, 0.84)
	rate	0.126 (0.084, 0.274)	0.113 (0.085, 0.157)	0.123 (0.074, 0.332)	0.12 (0.08, 0.302)	0.121 (0.074, 0.335)
-+-+	graduation	177	0	246	169	188
	futility	0	0	0	0	0
	max_n	13	0	17	17	15
	n	9 (3, 22)	21 (15, 28)	5 (0, 18)	10 (3, 22)	7 (2, 18)
	n_unique	8 (3, 20)	19 (14, 26)	4 (0, 16)	9 (3, 20)	6 (1, 16)
	post_p	0.43 (0.16, 0.84)	NA (NA, NA)	0.45 (0.18, 0.83)	0.47 (0.17, 0.86)	0.48 (0.18, 0.84)
	rate	0.128 (0.084, 0.289)	0.113 (0.083, 0.155)	0.13 (0.075, 0.408)	0.122 (0.08, 0.31)	0.123 (0.073, 0.344)
-++-	graduation	50	0	87	58	59
	futility	0	0	0	0	0
	max_n	6	0	7	8	12
	n	6 (2, 13)	12 (7, 16)	4 (1, 11)	6 (2, 13)	5 (1, 10)
	n_unique	5 (2, 12)	10 (6, 15)	4 (1, 9)	5 (2, 12)	4 (1, 10)
	post_p	0.47 (0.21, 0.83)	NA (NA, NA)	0.43 (0.23, 0.8)	0.44 (0.2, 0.84)	0.47 (0.23, 0.81)
	rate	0.124 (0.072, 0.33)	0.115 (0.073, 0.181)	0.134 (0.07, 0.43)	0.133 (0.073, 0.375)	0.128 (0.064, 0.48)
-+++	graduation	68	0	107	79	74
	futility	0	0	0	0	0
	max_n	7	0	7	8	14
	n	6 (2, 13)	12 (7, 17)	4 (1, 11)	6 (2, 13)	4 (1, 11)
	n_unique	5 (2, 12)	10 (7, 16)	4 (1, 10)	5 (2, 12)	4 (1, 10)
	post_p	0.46 (0.2, 0.82)	NA (NA, NA)	0.47 (0.21, 0.84)	0.44 (0.2, 0.84)	0.45 (0.19, 0.81)
	rate	0.123 (0.07, 0.328)	0.111 (0.074, 0.182)	0.126 (0.065, 0.379)	0.128 (0.071, 0.411)	0.132 (0.067, 0.415)
+—	graduation	2	0	22	3	5
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	8 (2, 17)	21 (14, 27)	9 (3, 19)	8 (3, 17)	10 (4, 22)
	n_unique	7 (2, 16)	19 (12, 25)	8 (2, 18)	7 (2, 16)	10 (3, 20)
	post_p	0.43 (0.18, 0.8)	NA (NA, NA)	0.49 (0.19, 0.82)	0.45 (0.19, 0.84)	0.48 (0.17, 0.86)
	rate	0.132 (0.076, 0.335)	0.115 (0.084, 0.161)	0.125 (0.078, 0.322)	0.125 (0.078, 0.301)	0.121 (0.082, 0.272)
+–+	graduation	23	0	53	31	30
	futility	0	0	0	0	0
	max_n	1	0	0	0	2
	n	6 (2, 15)	16 (11, 22)	7 (2, 15)	6 (2, 14)	9 (3, 18)
	n_unique	5 (2, 13)	15 (10, 20)	6 (2, 14)	5 (2, 13)	8 (3, 16)
	post_p	0.46 (0.2, 0.82)	NA (NA, NA)	0.46 (0.2, 0.85)	0.45 (0.22, 0.82)	0.46 (0.2, 0.84)
	rate	0.13 (0.075, 0.388)	0.116 (0.086, 0.168)	0.132 (0.08, 0.354)	0.131 (0.074, 0.426)	0.127 (0.079, 0.252)
+-+-	graduation	37	0	71	35	42
	futility	0	0	0	0	0
	max_n	6	0	7	8	12
	n	6 (2, 14)	16 (11, 22)	6 (2, 15)	6 (2, 14)	8 (3, 17)
	n_unique	6 (2, 13)	15 (10, 20)	6 (1, 14)	6 (2, 13)	8 (2, 16)
	post_p	0.45 (0.2, 0.8)	NA (NA, NA)	0.45 (0.21, 0.83)	0.45 (0.21, 0.81)	0.48 (0.18, 0.85)
	rate	0.131 (0.075, 0.334)	0.113 (0.076, 0.17)	0.123 (0.072, 0.415)	0.129 (0.071, 0.349)	0.123 (0.077, 0.289)
+-++	graduation	55	0	92	60	60
	futility	0	0	0	0	0
	max_n	7	0	7	8	14
	n	7 (2, 15)	16 (11, 23)	5 (2, 15)	6 (2, 14)	9 (3, 17)
	n_unique	6 (2, 14)	15 (10, 21)	5 (1, 14)	5 (2, 13)	8 (3, 16)
	post_p	0.45 (0.2, 0.82)	NA (NA, NA)	0.44 (0.19, 0.82)	0.44 (0.18, 0.82)	0.46 (0.18, 0.87)
	rate	0.128 (0.075, 0.335)	0.113 (0.079, 0.164)	0.133 (0.078, 0.364)	0.128 (0.074, 0.38)	0.123 (0.077, 0.262)
++–	graduation	19	0	40	29	24
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	6 (2, 13)	12 (7, 17)	4 (1, 10)	6 (2, 14)	4 (1, 11)
	n_unique	6 (2, 12)	10 (6, 16)	4 (1, 9)	6 (2, 13)	4 (1, 10)
	post_p	0.47 (0.2, 0.83)	NA (NA, NA)	0.44 (0.2, 0.8)	0.44 (0.22, 0.82)	0.46 (0.22, 0.81)
	rate	0.121 (0.067, 0.331)	0.113 (0.072, 0.165)	0.137 (0.062, 0.448)	0.128 (0.075, 0.372)	0.127 (0.063, 0.468)
++-+	graduation	39	0	69	53	46
	futility	0	0	0	0	0
	max_n	1	0	0	0	2
	n	6 (2, 12)	12 (7, 17)	4 (1, 10)	6 (2, 13)	5 (1, 11)
	n_unique	5 (2, 11)	11 (7, 16)	4 (1, 9)	5 (2, 12)	4 (1, 10)
	post_p	0.44 (0.19, 0.8)	NA (NA, NA)	0.44 (0.2, 0.79)	0.45 (0.2, 0.83)	0.44 (0.21, 0.78)
	rate	0.131 (0.073, 0.347)	0.112 (0.075, 0.17)	0.133 (0.068, 0.388)	0.129 (0.074, 0.357)	0.134 (0.065, 0.458)
+++-	graduation	50	0	87	58	59
	futility	0	0	0	0	0
	max_n	6	0	7	8	12
	n	6 (2, 13)	12 (7, 17)	4 (1, 10)	6 (2, 13)	5 (1, 11)
	n_unique	5 (2, 12)	11 (6, 16)	4 (1, 9)	5 (2, 11)	4 (1, 10)
	post_p	0.47 (0.2, 0.81)	NA (NA, NA)	0.47 (0.22, 0.77)	0.44 (0.19, 0.8)	0.47 (0.21, 0.82)
	rate	0.125 (0.074, 0.316)	0.115 (0.072, 0.182)	0.129 (0.067, 0.39)	0.129 (0.076, 0.386)	0.127 (0.064, 0.412)
++++	graduation	68	0	107	79	74
	futility	0	0	0	0	0
	max_n	7	0	7	8	14
	n	6 (2, 13)	12 (7, 17)	4 (1, 11)	5 (2, 13)	4 (1, 11)
	n_unique	6 (2, 12)	10 (6, 16)	4 (1, 10)	5 (2, 11)	4 (1, 9)
	post_p	0.48 (0.2, 0.81)	NA (NA, NA)	0.45 (0.24, 0.83)	0.43 (0.19, 0.83)	0.45 (0.21, 0.82)
	rate	0.125 (0.074, 0.334)	0.115 (0.077, 0.174)	0.132 (0.064, 0.411)	0.139 (0.075, 0.386)	0.131 (0.065, 0.469)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	11	4	1	1
	time_stop	4 (4, 6)	4 (4, 11)	6 (6, 6)	7 (7, 7)
	n_trt	34 (25, 50)	30 (26, 50)	25 (25, 25)	27 (27, 27)
	n_control	52 (37, 61)	54 (50, 108)	51 (51, 51)	80 (80, 80)
	post_p	0.87 (0.85, 0.96)	0.93 (0.92, 0.98)	0.98 (0.98, 0.98)	0.97 (0.97, 0.97)
	order	1 (1, 1)	1 (1, 1)	1 (1, 1)	1 (1, 1)
TP53- & AR-	count	50	44	24	22
	time_stop	10 (6, 21)	14 (9, 27)	15 (10, 27)	14 (9, 21)
	n_trt	31 (26, 66)	36 (26, 69)	33 (25, 68)	30 (26, 50)
	n_control	43 (27, 100)	60 (40, 116)	62 (37, 125)	61 (41, 87)
	post_p	0.9 (0.87, 0.95)	0.94 (0.86, 0.99)	0.94 (0.86, 0.99)	0.95 (0.9, 0.98)
	order	1 (1, 1)	1 (1, 2)	1 (1, 1.7)	1 (1, 1)
TP53+	count	14	4	3	2
	time_stop	10 (7, 14)	10 (8, 13)	12 (10, 13)	11 (10, 12)
	n_trt	28 (25, 39)	33 (31, 42)	33 (27, 35)	39 (30, 48)
	n_control	42 (32, 62)	41 (32, 59)	49 (35, 60)	42 (33, 50)
	post_p	0.94 (0.86, 0.97)	0.96 (0.94, 0.98)	0.94 (0.94, 0.95)	0.92 (0.87, 0.96)
	order	1 (1, 2)	1 (1, 1.7)	1 (1, 1)	1 (1, 1)
DRD+	count	3	1	2	2
	time_stop	21 (15, 22)	17 (17, 17)	16 (14, 18)	10 (10, 10)
	n_trt	25 (25, 34)	26 (26, 26)	27 (25, 29)	28 (26, 30)
	n_control	53 (31, 64)	47 (47, 47)	35 (33, 37)	30 (26, 33)
	post_p	0.98 (0.88, 0.98)	0.92 (0.92, 0.92)	0.88 (0.86, 0.9)	0.94 (0.91, 0.98)
	order	1 (1, 1.8)	1 (1, 1)	1 (1, 1)	1 (1, 1)
TEfus+	count	3	1	4	2
	time_stop	13 (11, 15)	11 (11, 11)	11 (10, 14)	15 (13, 17)
	n_trt	26 (25, 32)	31 (31, 31)	28 (26, 29)	41 (39, 43)
	n_control	44 (40, 52)	36 (36, 36)	42 (40, 50)	50 (40, 60)
	post_p	0.9 (0.87, 0.94)	0.95 (0.95, 0.95)	0.93 (0.87, 0.99)	1 (1, 1)
	order	1 (1, 1.8)	1 (1, 1)	1 (1, 1.7)	1 (1, 1)

Futility:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	11	1	1	2
	time_stop	5 (3, 5)	6 (6, 6)	7 (7, 7)	12 (8, 16)
	n_trt	31 (25, 39)	28 (28, 28)	38 (38, 38)	41 (32, 50)
	n_control	43 (33, 66)	75 (75, 75)	64 (64, 64)	140 (92, 187)
	post_p	0.04 (0.03, 0.28)	0.14 (0.14, 0.14)	0.01 (0.01, 0.01)	0.06 (0.01, 0.11)
	order	1 (1, 1)	1 (1, 1)	1 (1, 1)	1.5 (1.1, 1.9)
TP53- & AR-	count	161	116	128	119
	time_stop	15 (8, 32)	22 (15, 33)	22 (14, 34)	22 (14, 33)
	n_trt	36 (25, 75)	36 (25, 72)	34 (25, 80)	39 (26, 84)
	n_control	65 (30, 147)	101 (66, 158)	102 (59, 167)	101 (59, 159)
	post_p	0.17 (0.06, 0.28)	0.12 (0.03, 0.27)	0.16 (0.04, 0.26)	0.16 (0.06, 0.28)
	order	1 (1, 2)	2 (1, 3)	1 (1, 3)	2 (1, 3)
TP53+	count	38	33	32	31
	time_stop	20 (10, 28)	18 (10, 29)	22 (14, 34)	22 (13, 33)
	n_trt	42 (26, 69)	41 (28, 69)	44 (26, 75)	45 (27, 74)
	n_control	94 (38, 139)	85 (42, 159)	100 (66, 182)	107 (59, 171)
	post_p	0.06 (0.01, 0.22)	0.07 (0.03, 0.21)	0.05 (0.01, 0.15)	0.05 (0, 0.13)
	order	1 (1, 3)	2 (1, 3)	1 (1, 3)	2 (1, 4)
DRD+	count	16	18	15	25
	time_stop	31 (22, 35)	28 (22, 33)	24 (16, 33)	23 (16, 36)
	n_trt	32 (26, 49)	31 (25, 49)	37 (25, 51)	34 (28, 54)
	n_control	98 (64, 120)	84 (55, 99)	68 (45, 90)	69 (40, 114)
	post_p	0.05 (0.02, 0.15)	0.04 (0.01, 0.19)	0.08 (0.02, 0.18)	0.04 (0.02, 0.17)
	order	2 (1.5, 4)	2.5 (1.7, 4)	3 (1.4, 4)	2 (1, 3)
TEfus+	count	29	24	17	26
	time_stop	25 (18, 35)	22 (11, 32)	20 (13, 33)	24 (14, 36)
	n_trt	34 (26, 49)	40 (28, 62)	33 (26, 49)	44 (26, 70)
	n_control	105 (65, 140)	90 (36, 126)	88 (49, 137)	93 (46, 150)
	post_p	0.05 (0.02, 0.13)	0.05 (0.01, 0.13)	0.05 (0.02, 0.11)	0.04 (0.01, 0.16)
	order	2 (1, 4)	1.5 (1, 3)	2 (1, 3.4)	2 (1, 3.5)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Carboplatin	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)
		n	6 (6, 6)	0 (0, 0)	4 (4, 4)	0 (0, 0)	2 (2, 2)	4 (4, 4)	0 (0, 0)	2 (2, 2)	1 (1, 1)	0 (0, 0)	2 (2, 2)	0 (0, 0)	1 (1, 1)	1 (1, 1)	1 (1, 1)	1 (1, 1)
		post_p	0.56 (0.56, 0.56)	NA (NA, NA)	0.56 (0.56, 0.56)	NA (NA, NA)	0.67 (0.67, 0.67)	0.73 (0.73, 0.73)	NA (NA, NA)	0.58 (0.58, 0.58)	0.62 (0.62, 0.62)	NA (NA, NA)	0.59 (0.59, 0.59)	NA (NA, NA)	0.63 (0.63, 0.63)	0.51 (0.51, 0.51)	0.54 (0.54, 0.54)	0.52 (0.52, 0.52)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.091 (0.091, 0.091)	NA (NA, NA)	0.087 (0.087, 0.087)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Hormone_therapies	count	11	11	11	11	11	11	11	11	11	11	11	11	11	11	11	11
		time	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)
		n	14 (11, 19)	1 (1, 3)	9 (8, 18)	2 (0, 5)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 3)	1 (1, 3)	1 (1, 3)	1 (0, 1)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)
		post_p	0.64 (0.55, 0.88)	0.58 (0.54, 0.65)	0.73 (0.62, 0.83)	0.59 (0.53, 0.71)	NA (NA, NA)	0.54 (0.54, 0.63)	NA (NA, NA)	0.6 (0.52, 0.77)	0.55 (0.51, 0.69)	0.59 (0.51, 0.7)	0.62 (0.54, 0.64)	0.6 (0.54, 0.6)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.61 (0.56, 0.65)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.078 (0.047, 0.113)	0 (0, 0.007)	0.057 (0, 0.092)	0 (0, 0.305)	NA (NA, NA)	0 (0, 0.112)	NA (NA, NA)	0 (0, 0)	0 (0, 0.077)	0 (0, 0)	0 (0, 0)	0 (0, 0.088)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)
	Niraparib	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)
		n	2 (2, 2)	0 (0, 0)	4 (4, 4)	2 (2, 2)	6 (6, 6)	0 (0, 0)	0 (0, 0)	1 (1, 1)	1 (1, 1)	2 (2, 2)	0 (0, 0)	1 (1, 1)	0 (0, 0)	4 (4, 4)	2 (2, 2)	2 (2, 2)
		post_p	0.54 (0.54, 0.54)	NA (NA, NA)	0.7 (0.7, 0.7)	0.61 (0.61, 0.61)	0.62 (0.62, 0.62)	NA (NA, NA)	NA (NA, NA)	0.58 (0.58, 0.58)	0.51 (0.51, 0.51)	0.51 (0.51, 0.51)	NA (NA, NA)	0.54 (0.54, 0.54)	NA (NA, NA)	0.73 (0.73, 0.73)	0.64 (0.64, 0.64)	0.82 (0.82, 0.82)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0.044 (0.044, 0.044)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0.068 (0.068, 0.068)	0 (0, 0)	0 (0, 0)
	Taxel_therapies	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	4 (4, 11)	4 (4, 11)	4 (4, 11)	4 (4, 11)	4 (4, 11)	4 (4, 11)	4 (4, 11)	4 (4, 11)	4 (4, 11)	4 (4, 11)	4 (4, 11)	4 (4, 11)	4 (4, 11)	4 (4, 11)	4 (4, 11)	4 (4, 11)
		n	6 (4, 8)	2 (1, 5)	7 (2, 8)	6 (4, 8)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 4)	4 (2, 6)	4 (2, 4)	4 (1, 6)	0 (0, 2)	0 (0, 0)	0 (0, 2)	0 (0, 0)
		post_p	0.71 (0.61, 0.83)	0.58 (0.54, 0.69)	0.64 (0.63, 0.75)	0.72 (0.65, 0.8)	0.59 (0.59, 0.59)	0.61 (0.61, 0.61)	0.55 (0.53, 0.58)	0.52 (0.52, 0.52)	0.64 (0.63, 0.64)	0.6 (0.51, 0.83)	0.61 (0.53, 0.72)	0.58 (0.53, 0.83)	0.51 (0.51, 0.51)	NA (NA, NA)	0.57 (0.57, 0.57)	NA (NA, NA)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.038 (0, 0.099)	0 (0, 0.121)	0.068 (0.014, 0.096)	0 (0, 0.049)	0.119 (0.119, 0.119)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.163 (0.091, 0.235)	0 (0, 0)	0.033 (0, 0.187)	0.114 (0.023, 0.252)	0 (0, 0)	NA (NA, NA)	0.073 (0.073, 0.073)	NA (NA, NA)
DRD+	Carboplatin	count					2	2	2	2					2	2	2	2
		time					16 (14, 18)	16 (14, 18)	16 (14, 18)	16 (14, 18)					16 (14, 18)	16 (14, 18)	16 (14, 18)	16 (14, 18)
		n					6 (4, 8)	4 (2, 5)	4 (4, 4)	2 (0, 3)					2 (0, 4)	2 (2, 3)	2 (1, 4)	4 (2, 7)
		post_p					0.66 (0.59, 0.73)	0.56 (0.55, 0.57)	0.62 (0.6, 0.64)	0.56 (0.56, 0.56)					0.77 (0.77, 0.77)	0.65 (0.61, 0.68)	0.57 (0.54, 0.6)	0.71 (0.55, 0.87)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.069 (0.033, 0.105)	0.127 (0.124, 0.13)	0.061 (0.052, 0.069)	0.201 (0.201, 0.201)					0.057 (0.057, 0.057)	0.064 (0.013, 0.116)	0.03 (0.006, 0.054)	0.054 (0.011, 0.098)
	Hormone_therapies	count					3	3	3	3					3	3	3	3
		time					21 (15, 22)	21 (15, 22)	21 (15, 22)	21 (15, 22)					21 (15, 22)	21 (15, 22)	21 (15, 22)	21 (15, 22)
		n					5 (1, 5)	9 (3, 11)	3 (1, 8)	4 (1, 4)					1 (1, 3)	5 (2, 6)	4 (2, 5)	3 (1, 3)
		post_p					0.6 (0.57, 0.62)	0.78 (0.68, 0.89)	0.68 (0.54, 0.83)	0.59 (0.56, 0.62)					0.65 (0.63, 0.69)	0.68 (0.62, 0.76)	0.56 (0.53, 0.59)	0.68 (0.58, 0.82)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.098 (0.092, 0.103)	0.084 (0.046, 0.09)	0.102 (0.05, 0.154)	0.084 (0.068, 0.099)					0 (0, 0)	0.087 (0.065, 0.124)	0.08 (0.016, 0.174)	0 (0, 0.045)
	Niraparib	count					2	2	2	2					2	2	2	2
		time					10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)					10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)
		n					3 (3, 3)	6 (5, 7)	2 (2, 3)	2 (2, 3)					3 (2, 4)	4 (4, 5)	3 (3, 3)	4 (2, 6)
		post_p					0.64 (0.59, 0.68)	0.74 (0.7, 0.79)	0.83 (0.81, 0.84)	0.72 (0.62, 0.82)					0.61 (0.6, 0.62)	0.75 (0.64, 0.86)	0.55 (0.55, 0.56)	0.67 (0.54, 0.8)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.036 (0.007, 0.064)	0.101 (0.068, 0.133)	0 (0, 0)	0.107 (0.021, 0.193)					0.029 (0.006, 0.052)	0.035 (0.034, 0.036)	0.117 (0.114, 0.12)	0.039 (0.008, 0.07)
	Taxel_therapies	count					1	1	1	1					1	1	1	1
		time					17 (17, 17)	17 (17, 17)	17 (17, 17)	17 (17, 17)					17 (17, 17)	17 (17, 17)	17 (17, 17)	17 (17, 17)
		n					3 (3, 3)	5 (5, 5)	2 (2, 2)	1 (1, 1)					1 (1, 1)	3 (3, 3)	9 (9, 9)	2 (2, 2)
		post_p					0.6 (0.6, 0.6)	0.57 (0.57, 0.57)	0.85 (0.85, 0.85)	0.68 (0.68, 0.68)					0.74 (0.74, 0.74)	0.61 (0.61, 0.61)	0.81 (0.81, 0.81)	0.54 (0.54, 0.54)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.051 (0.051, 0.051)	0.094 (0.094, 0.094)	0.064 (0.064, 0.064)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0.077 (0.077, 0.077)	0 (0, 0)
TEfus+	Carboplatin	count		4		4		4		4		4		4		4		4
		time		11 (10, 14)		11 (10, 14)		11 (10, 14)		11 (10, 14)		11 (10, 14)		11 (10, 14)		11 (10, 14)		11 (10, 14)
		n		4 (2, 7)		4 (2, 8)		6 (3, 7)		4 (3, 5)		4 (2, 5)		0 (0, 2)		2 (0, 4)		4 (2, 4)
		post_p		0.74 (0.6, 0.86)		0.62 (0.57, 0.85)		0.64 (0.51, 0.85)		0.61 (0.54, 0.85)		0.57 (0.52, 0.73)		0.54 (0.54, 0.55)		0.71 (0.61, 0.8)		0.58 (0.56, 0.65)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.027 (0, 0.083)		0 (0, 0.079)		0.061 (0.053, 0.09)		0.073 (0.059, 0.1)		0.042 (0, 0.135)		0 (0, 0)		0.094 (0.082, 0.106)		0.09 (0.073, 0.097)
	Hormone_therapies	count		3		3		3		3		3		3		3		3
		time		13 (11, 15)		13 (11, 15)		13 (11, 15)		13 (11, 15)		13 (11, 15)		13 (11, 15)		13 (11, 15)		13 (11, 15)
		n		4 (2, 5)		13 (12, 17)		2 (1, 6)		0 (0, 2)		3 (1, 4)		3 (1, 4)		0 (0, 1)		0 (0, 1)
		post_p		0.66 (0.6, 0.71)		0.73 (0.71, 0.75)		0.56 (0.55, 0.88)		0.62 (0.62, 0.62)		0.77 (0.65, 0.78)		0.58 (0.54, 0.63)		0.56 (0.56, 0.56)		NA (NA, NA)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.098 (0.02, 0.099)		0.091 (0.076, 0.104)		0.032 (0.006, 0.085)		0 (0, 0)		0.079 (0.016, 0.1)		0.066 (0.059, 0.074)		0 (0, 0)		0 (0, 0)
	Niraparib	count		2		2		2		2		2		2		2		2
		time		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)
		n		4 (3, 4)		12 (11, 14)		6 (5, 8)		6 (4, 8)		4 (2, 6)		1 (1, 1)		4 (3, 5)		4 (3, 4)
		post_p		0.56 (0.53, 0.58)		0.83 (0.81, 0.86)		0.75 (0.72, 0.78)		0.77 (0.76, 0.79)		0.75 (0.7, 0.8)		0.56 (0.53, 0.6)		0.68 (0.63, 0.73)		0.58 (0.57, 0.6)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.119 (0.112, 0.127)		0.045 (0.044, 0.046)		0.051 (0.043, 0.059)		0.02 (0.004, 0.037)		0.033 (0.007, 0.06)		0 (0, 0)		0.13 (0.074, 0.185)		0.074 (0.069, 0.078)
	Taxel_therapies	count		1		1		1		1		1		1		1		1
		time		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)
		n		1 (1, 1)		19 (19, 19)		2 (2, 2)		0 (0, 0)		2 (2, 2)		6 (6, 6)		1 (1, 1)		0 (0, 0)
		post_p		0.73 (0.73, 0.73)		0.82 (0.82, 0.82)		0.6 (0.6, 0.6)		NA (NA, NA)		0.63 (0.63, 0.63)		0.77 (0.77, 0.77)		0.61 (0.61, 0.61)		NA (NA, NA)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0 (0, 0)		0.031 (0.031, 0.031)		0 (0, 0)		NA (NA, NA)		0.169 (0.169, 0.169)		0.163 (0.163, 0.163)		0 (0, 0)		NA (NA, NA)
TP53- & AR-	Carboplatin	count	24	24			24	24
		time	15 (10, 27)	15 (10, 27)			15 (10, 27)	15 (10, 27)
		n	19 (10, 42)	4 (0, 12)			6 (4, 12)	6 (2, 11)
		post_p	0.81 (0.71, 0.92)	0.69 (0.59, 0.85)			0.78 (0.53, 0.91)	0.71 (0.52, 0.85)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.07 (0.027, 0.095)	0.056 (0, 0.109)			0.068 (0.033, 0.142)	0.08 (0.039, 0.147)
	Hormone_therapies	count	50	50			50	50
		time	10 (6, 21)	10 (6, 21)			10 (6, 21)	10 (6, 21)
		n	26 (21, 50)	4 (2, 8)			1 (0, 5)	1 (0, 10)
		post_p	0.85 (0.74, 0.92)	0.69 (0.55, 0.83)			0.57 (0.51, 0.72)	0.54 (0.52, 0.8)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.081 (0.051, 0.097)	0.062 (0, 0.126)			0 (0, 0.095)	0 (0, 0.106)
	Niraparib	count	22	22			22	22
		time	14 (9, 21)	14 (9, 21)			14 (9, 21)	14 (9, 21)
		n	18 (12, 34)	2 (0, 6)			6 (3, 11)	5 (3, 11)
		post_p	0.8 (0.73, 0.9)	0.61 (0.52, 0.82)			0.78 (0.59, 0.89)	0.72 (0.54, 0.88)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.07 (0.028, 0.083)	0.036 (0, 0.108)			0.061 (0.003, 0.115)	0.075 (0.002, 0.106)
	Taxel_therapies	count	44	44			44	44
		time	14 (9, 27)	14 (9, 27)			14 (9, 27)	14 (9, 27)
		n	22 (18, 39)	5 (1, 12)			3 (1, 12)	3 (0, 8)
		post_p	0.83 (0.72, 0.96)	0.73 (0.53, 0.89)			0.62 (0.52, 0.83)	0.67 (0.52, 0.86)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.076 (0.037, 0.099)	0.065 (0, 0.122)			0.057 (0, 0.113)	0.058 (0, 0.141)
TP53+	Carboplatin	count			3	3			3	3			3	3			3	3
		time			12 (10, 13)	12 (10, 13)			12 (10, 13)	12 (10, 13)			12 (10, 13)	12 (10, 13)			12 (10, 13)	12 (10, 13)
		n			12 (6, 17)	4 (3, 4)			3 (2, 5)	5 (1, 5)			2 (1, 5)	1 (0, 3)			1 (1, 2)	4 (2, 5)
		post_p			0.78 (0.58, 0.82)	0.57 (0.53, 0.67)			0.57 (0.54, 0.58)	0.84 (0.74, 0.95)			0.72 (0.61, 0.75)	0.53 (0.51, 0.54)			0.64 (0.55, 0.67)	0.61 (0.56, 0.82)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.053 (0.022, 0.154)	0.071 (0.067, 0.073)			0.081 (0.059, 0.153)	0.03 (0.024, 0.036)			0.092 (0.018, 0.101)	0.056 (0.011, 0.102)			0.099 (0.02, 0.11)	0 (0, 0.104)
	Hormone_therapies	count			14	14			14	14			14	14			14	14
		time			10 (7, 14)	10 (7, 14)			10 (7, 14)	10 (7, 14)			10 (7, 14)	10 (7, 14)			10 (7, 14)	10 (7, 14)
		n			15 (11, 18)	6 (2, 11)			0 (0, 3)	1 (0, 4)			2 (0, 5)	3 (0, 5)			0 (0, 3)	1 (0, 2)
		post_p			0.8 (0.71, 0.88)	0.75 (0.56, 0.86)			0.55 (0.52, 0.64)	0.59 (0.53, 0.69)			0.7 (0.58, 0.76)	0.61 (0.55, 0.73)			0.62 (0.56, 0.73)	0.61 (0.55, 0.79)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.077 (0.043, 0.108)	0.064 (0, 0.102)			0 (0, 0.041)	0 (0, 0.087)			0 (0, 0.088)	0.032 (0, 0.121)			0 (0, 0.151)	0 (0, 0.031)
	Niraparib	count			2	2			2	2			2	2			2	2
		time			11 (10, 12)	11 (10, 12)			11 (10, 12)	11 (10, 12)			11 (10, 12)	11 (10, 12)			11 (10, 12)	11 (10, 12)
		n			15 (10, 20)	2 (2, 3)			4 (4, 5)	3 (2, 4)			4 (3, 5)	2 (1, 2)			4 (2, 5)	5 (3, 7)
		post_p			0.76 (0.72, 0.8)	0.64 (0.59, 0.69)			0.64 (0.58, 0.71)	0.57 (0.52, 0.62)			0.7 (0.7, 0.7)	0.56 (0.53, 0.59)			0.55 (0.54, 0.56)	0.76 (0.74, 0.78)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.069 (0.068, 0.07)	0 (0, 0)			0.08 (0.072, 0.088)	0.122 (0.094, 0.15)			0.031 (0.006, 0.055)	0 (0, 0)			0.119 (0.102, 0.136)	0.027 (0.005, 0.049)
	Taxel_therapies	count			4	4			4	4			4	4			4	4
		time			10 (8, 13)	10 (8, 13)			10 (8, 13)	10 (8, 13)			10 (8, 13)	10 (8, 13)			10 (8, 13)	10 (8, 13)
		n			11 (10, 13)	12 (8, 18)			2 (0, 3)	0 (0, 1)			2 (1, 3)	4 (3, 6)			1 (1, 2)	2 (0, 3)
		post_p			0.78 (0.72, 0.84)	0.83 (0.76, 0.88)			0.55 (0.53, 0.7)	0.56 (0.56, 0.56)			0.57 (0.52, 0.66)	0.68 (0.53, 0.78)			0.67 (0.56, 0.68)	0.6 (0.53, 0.65)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.07 (0.016, 0.093)	0.066 (0.044, 0.07)			0 (0, 0.028)	0 (0, 0)			0.074 (0, 0.177)	0.098 (0.057, 0.149)			0 (0, 0.297)	0 (0, 0.07)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Carboplatin	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)
		n	5 (5, 5)	2 (2, 2)	6 (6, 6)	3 (3, 3)	0 (0, 0)	1 (1, 1)	2 (2, 2)	2 (2, 2)	5 (5, 5)	0 (0, 0)	2 (2, 2)	2 (2, 2)	4 (4, 4)	3 (3, 3)	0 (0, 0)	1 (1, 1)
		post_p	0.28 (0.28, 0.28)	0.38 (0.38, 0.38)	0.28 (0.28, 0.28)	0.43 (0.43, 0.43)	NA (NA, NA)	0.23 (0.23, 0.23)	0.21 (0.21, 0.21)	0.27 (0.27, 0.27)	0.35 (0.35, 0.35)	NA (NA, NA)	0.36 (0.36, 0.36)	0.47 (0.47, 0.47)	0.4 (0.4, 0.4)	0.38 (0.38, 0.38)	NA (NA, NA)	0.47 (0.47, 0.47)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.248 (0.248, 0.248)	0.269 (0.269, 0.269)	0.179 (0.179, 0.179)	0.164 (0.164, 0.164)	NA (NA, NA)	2.439 (2.439, 2.439)	1.674 (1.674, 1.674)	0.9 (0.9, 0.9)	0.192 (0.192, 0.192)	NA (NA, NA)	0.32 (0.32, 0.32)	0.335 (0.335, 0.335)	0.153 (0.153, 0.153)	0.083 (0.083, 0.083)	NA (NA, NA)	0 (0, 0)
	Hormone_therapies	count	11	11	11	11	11	11	11	11	11	11	11	11	11	11	11	11
		time	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)
		n	15 (12, 19)	2 (0, 5)	6 (4, 11)	2 (2, 5)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 1)	1 (0, 3)	1 (0, 2)	0 (0, 3)	1 (0, 4)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 1)
		post_p	0.29 (0.18, 0.47)	0.39 (0.32, 0.45)	0.25 (0.14, 0.37)	0.38 (0.29, 0.47)	0.39 (0.27, 0.49)	0.29 (0.29, 0.29)	0.28 (0.25, 0.32)	0.4 (0.4, 0.4)	0.48 (0.39, 0.49)	0.3 (0.26, 0.4)	0.31 (0.27, 0.35)	0.4 (0.28, 0.47)	0.35 (0.31, 0.4)	0.42 (0.42, 0.42)	0.43 (0.4, 0.47)	0.28 (0.28, 0.28)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.162 (0.096, 0.21)	0.244 (0.115, 0.427)	0.204 (0.077, 0.398)	0.19 (0.114, 1.114)	0.067 (0, 0.682)	0.356 (0.356, 0.356)	0.433 (0.087, 0.945)	0.098 (0.02, 0.177)	0.151 (0, 0.439)	0.463 (0.193, 0.988)	0.114 (0, 0.537)	0 (0, 0.214)	3.829 (0.863, 6.794)	0.351 (0.351, 0.351)	0.087 (0.017, 0.157)	0 (0, 0.291)
	Niraparib	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	12 (8, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)
		n	4 (3, 4)	2 (0, 3)	7 (6, 8)	2 (0, 3)	4 (2, 5)	6 (5, 7)	3 (1, 5)	1 (1, 1)	0 (0, 1)	2 (1, 3)	0 (0, 1)	1 (0, 2)	2 (1, 2)	4 (4, 4)	4 (2, 6)	0 (0, 1)
		post_p	0.37 (0.33, 0.41)	0.24 (0.24, 0.24)	0.28 (0.13, 0.42)	0.16 (0.16, 0.16)	0.36 (0.31, 0.41)	0.35 (0.35, 0.36)	0.39 (0.39, 0.39)	0.33 (0.33, 0.33)	0.32 (0.32, 0.32)	0.36 (0.34, 0.38)	0.46 (0.46, 0.46)	0.44 (0.44, 0.44)	0.26 (0.24, 0.28)	0.36 (0.34, 0.37)	0.37 (0.34, 0.4)	0.45 (0.45, 0.45)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.228 (0.225, 0.23)	0.52 (0.52, 0.52)	0.164 (0.142, 0.185)	0.283 (0.283, 0.283)	0.366 (0.177, 0.555)	0.137 (0.117, 0.157)	0.103 (0.103, 0.103)	0.294 (0.226, 0.361)	0.733 (0.733, 0.733)	2.82 (0.687, 4.954)	0.293 (0.293, 0.293)	0 (0, 0)	1.243 (0.446, 2.039)	0.164 (0.152, 0.177)	4.739 (1.034, 8.444)	0.143 (0.143, 0.143)
	Taxel_therapies	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)
		n	6 (6, 6)	1 (1, 1)	3 (3, 3)	6 (6, 6)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (1, 1)	1 (1, 1)	2 (2, 2)	4 (4, 4)	4 (4, 4)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		post_p	0.48 (0.48, 0.48)	0.46 (0.46, 0.46)	0.44 (0.44, 0.44)	0.32 (0.32, 0.32)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.44 (0.44, 0.44)	0.5 (0.5, 0.5)	0.43 (0.43, 0.43)	0.28 (0.28, 0.28)	0.33 (0.33, 0.33)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.118 (0.118, 0.118)	0 (0, 0)	0.183 (0.183, 0.183)	0.228 (0.228, 0.228)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0.167 (0.167, 0.167)	0.178 (0.178, 0.178)	0.145 (0.145, 0.145)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
DRD+	Carboplatin	count					15	15	15	15					15	15	15	15
		time					24 (16, 33)	24 (16, 33)	24 (16, 33)	24 (16, 33)					24 (16, 33)	24 (16, 33)	24 (16, 33)	24 (16, 33)
		n					7 (1, 15)	6 (2, 11)	2 (0, 7)	3 (2, 6)					4 (1, 7)	3 (1, 7)	5 (2, 10)	4 (2, 7)
		post_p					0.4 (0.25, 0.46)	0.39 (0.18, 0.46)	0.3 (0.24, 0.46)	0.34 (0.2, 0.45)					0.38 (0.28, 0.45)	0.36 (0.2, 0.45)	0.33 (0.24, 0.47)	0.37 (0.24, 0.49)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.163 (0.122, 0.331)	0.149 (0.107, 0.4)	0.207 (0.124, 0.577)	0.207 (0.112, 0.431)					0.189 (0.121, 0.809)	0.196 (0.14, 1.101)	0.183 (0.093, 0.425)	0.189 (0.135, 0.343)
	Hormone_therapies	count					16	16	16	16					16	16	16	16
		time					31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)					31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)
		n					4 (2, 19)	4 (2, 7)	4 (2, 9)	4 (2, 8)					3 (2, 6)	3 (2, 6)	3 (0, 8)	3 (2, 5)
		post_p					0.38 (0.19, 0.49)	0.28 (0.13, 0.45)	0.32 (0.25, 0.45)	0.4 (0.3, 0.45)					0.33 (0.25, 0.46)	0.33 (0.18, 0.44)	0.35 (0.2, 0.45)	0.37 (0.18, 0.48)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.142 (0.108, 0.34)	0.188 (0.129, 0.591)	0.157 (0.115, 0.428)	0.165 (0.097, 0.615)					0.186 (0.133, 0.281)	0.217 (0.14, 0.334)	0.18 (0.142, 0.4)	0.191 (0.144, 0.38)
	Niraparib	count					25	25	25	25					25	25	25	25
		time					23 (16, 36)	23 (16, 36)	23 (16, 36)	23 (16, 36)					23 (16, 36)	23 (16, 36)	23 (16, 36)	23 (16, 36)
		n					6 (3, 12)	5 (2, 12)	4 (2, 8)	3 (1, 9)					3 (2, 8)	3 (2, 7)	3 (2, 11)	4 (1, 9)
		post_p					0.38 (0.13, 0.48)	0.34 (0.2, 0.47)	0.34 (0.22, 0.49)	0.33 (0.14, 0.48)					0.33 (0.16, 0.49)	0.36 (0.16, 0.45)	0.36 (0.22, 0.47)	0.35 (0.21, 0.48)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.161 (0.102, 0.347)	0.164 (0.117, 0.312)	0.174 (0.1, 0.541)	0.196 (0.109, 0.623)					0.186 (0.094, 0.75)	0.169 (0.122, 0.38)	0.197 (0.085, 0.368)	0.18 (0.127, 0.524)
	Taxel_therapies	count					18	18	18	18					18	18	18	18
		time					28 (22, 33)	28 (22, 33)	28 (22, 33)	28 (22, 33)					28 (22, 33)	28 (22, 33)	28 (22, 33)	28 (22, 33)
		n					6 (2, 13)	3 (1, 12)	3 (1, 7)	4 (1, 6)					4 (1, 7)	4 (1, 6)	3 (2, 7)	2 (1, 5)
		post_p					0.41 (0.23, 0.48)	0.37 (0.2, 0.48)	0.35 (0.24, 0.48)	0.35 (0.12, 0.46)					0.35 (0.23, 0.47)	0.35 (0.18, 0.47)	0.37 (0.2, 0.47)	0.34 (0.19, 0.46)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.159 (0.107, 0.344)	0.176 (0.113, 2.086)	0.174 (0.093, 0.543)	0.208 (0.119, 0.684)					0.179 (0.116, 0.516)	0.228 (0.128, 0.618)	0.168 (0.114, 0.376)	0.212 (0.123, 0.473)
TEfus+	Carboplatin	count		17		17		17		17		17		17		17		17
		time		20 (13, 33)		20 (13, 33)		20 (13, 33)		20 (13, 33)		20 (13, 33)		20 (13, 33)		20 (13, 33)		20 (13, 33)
		n		4 (2, 8)		8 (2, 15)		5 (3, 8)		3 (1, 6)		3 (1, 9)		3 (1, 10)		3 (1, 6)		4 (3, 7)
		post_p		0.36 (0.19, 0.44)		0.32 (0.14, 0.45)		0.4 (0.2, 0.48)		0.38 (0.2, 0.49)		0.36 (0.27, 0.48)		0.37 (0.24, 0.49)		0.35 (0.19, 0.46)		0.37 (0.18, 0.47)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.182 (0.111, 0.323)		0.175 (0.113, 0.622)		0.161 (0.1, 0.307)		0.151 (0.091, 3.734)		0.173 (0.124, 0.364)		0.162 (0.1, 0.734)		0.172 (0.141, 0.523)		0.168 (0.117, 0.366)
	Hormone_therapies	count		29		29		29		29		29		29		29		29
		time		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)		25 (18, 35)
		n		5 (2, 11)		8 (5, 20)		2 (0, 6)		3 (1, 7)		3 (1, 8)		4 (2, 7)		2 (1, 7)		2 (1, 4)
		post_p		0.35 (0.21, 0.48)		0.31 (0.12, 0.44)		0.35 (0.24, 0.46)		0.37 (0.19, 0.48)		0.31 (0.19, 0.45)		0.37 (0.21, 0.48)		0.35 (0.18, 0.47)		0.35 (0.26, 0.48)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.177 (0.11, 0.494)		0.142 (0.116, 0.284)		0.212 (0.113, 0.916)		0.206 (0.106, 0.467)		0.226 (0.118, 0.726)		0.177 (0.123, 0.447)		0.223 (0.118, 0.585)		0.234 (0.111, 0.376)
	Niraparib	count		26		26		26		26		26		26		26		26
		time		24 (14, 36)		24 (14, 36)		24 (14, 36)		24 (14, 36)		24 (14, 36)		24 (14, 36)		24 (14, 36)		24 (14, 36)
		n		5 (2, 12)		6 (2, 24)		5 (2, 16)		3 (1, 8)		4 (1, 10)		3 (1, 7)		4 (2, 8)		3 (1, 6)
		post_p		0.35 (0.21, 0.47)		0.38 (0.19, 0.49)		0.32 (0.17, 0.45)		0.33 (0.19, 0.47)		0.37 (0.21, 0.48)		0.41 (0.24, 0.49)		0.33 (0.19, 0.46)		0.34 (0.18, 0.48)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.159 (0.116, 0.302)		0.125 (0.109, 0.365)		0.16 (0.117, 0.402)		0.176 (0.1, 0.46)		0.152 (0.087, 1.138)		0.167 (0.105, 0.36)		0.176 (0.113, 0.359)		0.18 (0.129, 0.467)
	Taxel_therapies	count		24		24		24		24		24		24		24		24
		time		22 (11, 32)		22 (11, 32)		22 (11, 32)		22 (11, 32)		22 (11, 32)		22 (11, 32)		22 (11, 32)		22 (11, 32)
		n		6 (5, 11)		10 (6, 27)		3 (1, 8)		1 (0, 4)		5 (2, 10)		5 (2, 10)		1 (0, 3)		2 (0, 6)
		post_p		0.36 (0.14, 0.49)		0.36 (0.17, 0.46)		0.37 (0.21, 0.45)		0.35 (0.16, 0.43)		0.35 (0.19, 0.47)		0.37 (0.23, 0.49)		0.31 (0.24, 0.44)		0.32 (0.23, 0.47)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.148 (0.103, 0.218)		0.146 (0.112, 0.181)		0.189 (0.125, 0.733)		0.298 (0.151, 3.27)		0.161 (0.105, 0.32)		0.15 (0.097, 0.218)		0.299 (0.093, 0.925)		0.193 (0.102, 0.365)
TP53- & AR-	Carboplatin	count	128	128			128	128
		time	22 (14, 34)	22 (14, 34)			22 (14, 34)	22 (14, 34)
		n	18 (7, 52)	4 (1, 11)			7 (2, 13)	6 (2, 13)
		post_p	0.35 (0.11, 0.47)	0.34 (0.19, 0.48)			0.36 (0.2, 0.47)	0.34 (0.16, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.128 (0.107, 0.25)	0.165 (0.108, 0.666)			0.156 (0.108, 0.328)	0.159 (0.104, 0.6)
	Hormone_therapies	count	161	161			161	161
		time	15 (8, 32)	15 (8, 32)			15 (8, 32)	15 (8, 32)
		n	25 (17, 54)	5 (2, 10)			3 (0, 8)	3 (1, 8)
		post_p	0.33 (0.14, 0.46)	0.36 (0.17, 0.48)			0.38 (0.21, 0.48)	0.37 (0.2, 0.49)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.126 (0.105, 0.16)	0.175 (0.1, 0.439)			0.171 (0.102, 0.509)	0.175 (0.099, 0.553)
	Niraparib	count	119	119			119	119
		time	22 (14, 33)	22 (14, 33)			22 (14, 33)	22 (14, 33)
		n	22 (8, 57)	4 (1, 10)			7 (3, 14)	6 (2, 13)
		post_p	0.35 (0.11, 0.47)	0.36 (0.21, 0.47)			0.36 (0.15, 0.48)	0.35 (0.13, 0.47)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.127 (0.101, 0.188)	0.162 (0.11, 0.517)			0.144 (0.101, 0.457)	0.156 (0.106, 0.422)
	Taxel_therapies	count	116	116			116	116
		time	22 (15, 33)	22 (15, 33)			22 (15, 33)	22 (15, 33)
		n	19 (9, 52)	6 (2, 14)			5 (2, 10)	4 (2, 10)
		post_p	0.29 (0.07, 0.45)	0.35 (0.16, 0.47)			0.37 (0.17, 0.48)	0.36 (0.21, 0.48)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.135 (0.106, 0.207)	0.144 (0.103, 0.347)			0.164 (0.106, 0.529)	0.153 (0.104, 0.44)
TP53+	Carboplatin	count			32	32			32	32			32	32			32	32
		time			22 (14, 34)	22 (14, 34)			22 (14, 34)	22 (14, 34)			22 (14, 34)	22 (14, 34)			22 (14, 34)	22 (14, 34)
		n			13 (4, 29)	7 (2, 14)			3 (1, 7)	3 (1, 8)			5 (2, 11)	4 (1, 7)			4 (2, 7)	4 (1, 9)
		post_p			0.35 (0.1, 0.46)	0.35 (0.14, 0.46)			0.34 (0.18, 0.47)	0.36 (0.16, 0.45)			0.4 (0.23, 0.48)	0.33 (0.15, 0.48)			0.37 (0.23, 0.48)	0.39 (0.22, 0.47)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.137 (0.104, 0.325)	0.147 (0.109, 0.434)			0.19 (0.099, 0.622)	0.191 (0.097, 0.948)			0.144 (0.109, 0.357)	0.192 (0.115, 0.343)			0.166 (0.098, 0.427)	0.168 (0.093, 0.31)
	Hormone_therapies	count			38	38			38	38			38	38			38	38
		time			20 (10, 28)	20 (10, 28)			20 (10, 28)	20 (10, 28)			20 (10, 28)	20 (10, 28)			20 (10, 28)	20 (10, 28)
		n			16 (9, 36)	7 (2, 19)			2 (0, 4)	2 (0, 6)			4 (1, 7)	3 (1, 5)			2 (0, 6)	2 (1, 4)
		post_p			0.32 (0.09, 0.47)	0.32 (0.12, 0.48)			0.35 (0.22, 0.47)	0.36 (0.19, 0.48)			0.36 (0.25, 0.48)	0.34 (0.17, 0.46)			0.38 (0.29, 0.44)	0.4 (0.27, 0.48)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.129 (0.103, 0.182)	0.149 (0.109, 0.614)			0.212 (0.099, 0.94)	0.209 (0.102, 0.923)			0.184 (0.101, 1.892)	0.21 (0.111, 0.478)			0.205 (0.099, 0.758)	0.202 (0.087, 0.348)
	Niraparib	count			31	31			31	31			31	31			31	31
		time			22 (13, 33)	22 (13, 33)			22 (13, 33)	22 (13, 33)			22 (13, 33)	22 (13, 33)			22 (13, 33)	22 (13, 33)
		n			9 (3, 26)	9 (4, 23)			4 (1, 7)	3 (2, 6)			4 (1, 8)	2 (1, 9)			5 (2, 7)	4 (1, 9)
		post_p			0.28 (0.15, 0.41)	0.32 (0.16, 0.48)			0.36 (0.23, 0.47)	0.33 (0.15, 0.48)			0.34 (0.18, 0.45)	0.36 (0.18, 0.46)			0.43 (0.19, 0.49)	0.35 (0.17, 0.48)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.14 (0.115, 0.371)	0.155 (0.107, 0.335)			0.172 (0.106, 0.387)	0.202 (0.125, 0.425)			0.187 (0.124, 0.404)	0.255 (0.118, 0.856)			0.126 (0.09, 0.344)	0.195 (0.117, 0.63)
	Taxel_therapies	count			33	33			33	33			33	33			33	33
		time			18 (10, 29)	18 (10, 29)			18 (10, 29)	18 (10, 29)			18 (10, 29)	18 (10, 29)			18 (10, 29)	18 (10, 29)
		n			10 (4, 36)	10 (5, 18)			1 (0, 5)	2 (0, 7)			4 (1, 8)	5 (1, 10)			2 (0, 6)	3 (1, 5)
		post_p			0.35 (0.21, 0.46)	0.33 (0.15, 0.45)			0.4 (0.25, 0.49)	0.38 (0.2, 0.48)			0.39 (0.23, 0.49)	0.36 (0.2, 0.48)			0.36 (0.19, 0.49)	0.32 (0.19, 0.48)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.131 (0.111, 0.215)	0.133 (0.092, 0.191)			0.214 (0.088, 0.673)	0.212 (0.09, 0.814)			0.159 (0.112, 0.318)	0.145 (0.081, 0.455)			0.206 (0.139, 1)	0.202 (0.081, 0.791)